CAJ | 학술논문

　　目的?探讨臭氧联合阿德福韦酯胶囊治疗乙型肝炎的效果，并进行安全性评估。方法?选择我院80例乙型肝炎患者随机分为对照组和观察组，每组40例，对照组患者采用阿德福韦酯胶囊治疗，观察组患者采用臭氧联合阿德福韦酯胶囊治疗，疗程结束后，观察两组患者治疗后3、6、12、18个月HBV-DNA、HbeAg转阴率、病毒应答及不良反应。结果?观察组在治疗后12、18个月血清HBV-DNA、HbeAg转阴率均高于对照组，完全应答与持续应答率明显高于对照组，无应答率低于对照组，两组间比较差异具有显著性（P＜0.05）。观察组在臭氧治疗过程中出现1例不良反应，发生率为2.5%；对照组无明显不良反应病例。结论?臭氧联合阿德福韦酯胶囊治疗乙型肝炎具有治疗效果好、见效快的优点，且无明显的不良反应，安全性较高。
　　목적?탐토취양연합아덕복위지효낭치료을형간염적효과，병진행안전성평고。방법?선택아원80례을형간염환자수궤분위대조조화관찰조，매조40례，대조조환자채용아덕복위지효낭치료，관찰조환자채용취양연합아덕복위지효낭치료，료정결속후，관찰량조환자치료후3、6、12、18개월HBV-DNA、HbeAg전음솔、병독응답급불량반응。결과?관찰조재치료후12、18개월혈청HBV-DNA、HbeAg전음솔균고우대조조，완전응답여지속응답솔명현고우대조조，무응답솔저우대조조，량조간비교차이구유현저성（P＜0.05）。관찰조재취양치료과정중출현1례불량반응，발생솔위2.5%；대조조무명현불량반응병례。결론?취양연합아덕복위지효낭치료을형간염구유치료효과호、견효쾌적우점，차무명현적불량반응，안전성교고。
Objective?To?study?the?effect?of?ozone?combined?with?adefovir?dipivoxil?capsules?for?the?treatment?of?hepatitis?B,?and?safety?assessment.?Method?Select?our?hospital?80?cases?of?hepatitis?B?were?randomLy?divided?into?control?group?and?observation?group,?40?cases?in?each?group,?the?control?group?were?treated?with?adefovir?dipivoxil?capsules?treatment,?the?observation?group?were?treated?with?ozone?combined?with?adefovir?dipivoxil?capsules?treatment?the?end?of?treatment?was?observed?after?3,?6,?12,?18?months?after?the?treatment?of?the?two?groups?of?patients?with?HBV-DNA,?HBeAg-negative?rate?of?virologic?response?and?adverse?reactions.?Results?The?12?and?18?months?of?serum?HBV-DNA,?HBeAg-negative?rate?was?higher?complete?response?and?sustained?response?rate?after?treatment?was?signiifcantly?higher?response?rate?than?the?control?group,?two?groupsThe?difference?being?signiifcant?(P<0.05).?Observation?group?in?the?process?of?ozone?therapy?in?cases?of?adverse?reactions,?the?rate?was?2.5%;?no?signiifcant?adverse?reactions?occurred?in?the?control?group.?Conclusion?Ozone?combined?with?adefovir?dipivoxil?capsules?treatment?of?hepatitis?B?with?a?good?therapeutic?effect,?the?advantages?of?quick,?and?no?signiifcant?adverse?reactions,?high?security.