CAJ | 학술논문

甲状腺功能减退症是指甲状腺激素缺乏或生物效应不足，以机体的代谢和多系统功能减退为特征的一组代谢紊乱综合征，是较常见的内分泌疾病。临床上表现为怕冷、乏力、困倦、便秘等，目前的治疗主要是甲状腺素替代。原发性甲状腺功能减退症占甲状腺功能减退症的90％～95％，是源于甲状腺本身的病变。本例甲状腺功能减退症患者因甲状腺激素低下，负反馈减弱致垂体促甲状腺激素（ TSH）细胞增生肥大、 TSH水平升高，垂体增生，同时催乳素升高，而促肾上腺皮质激素（ ACTH）和生长激素相对减低；经过甲状腺素（如优甲乐）替代治疗，随着甲状腺功能减退症的纠正，肥大的垂体明显缩小，催乳素、 ACTH、生长激素等激素水平也恢复正常。
갑상선공능감퇴증시지갑상선격소결핍혹생물효응불족，이궤체적대사화다계통공능감퇴위특정적일조대사문란종합정，시교상견적내분비질병。림상상표현위파랭、핍력、곤권、편비등，목전적치료주요시갑상선소체대。원발성갑상선공능감퇴증점갑상선공능감퇴증적90％～95％，시원우갑상선본신적병변。본례갑상선공능감퇴증환자인갑상선격소저하，부반궤감약치수체촉갑상선격소（ TSH）세포증생비대、 TSH수평승고，수체증생，동시최유소승고，이촉신상선피질격소（ ACTH）화생장격소상대감저；경과갑상선소（여우갑악）체대치료，수착갑상선공능감퇴증적규정，비대적수체명현축소，최유소、 ACTH、생장격소등격소수평야회복정상。
Hypothyroidism is a common endocrine disease.It refers to the lack or low biological effects of thyroid hor-mone ( TH) , it is a group of metabolic disorders syndrome which is characterized by declines of the metabolism and multi -sys-tem.Its clinical presentation includes the cold , fatigue, sleepiness, constipation, etc.The current treatment is mainly the thy-roid hormone replacement therapy.Primary hypothyroidism accounted for about 90%-95%of the hypothyroidism , which is due to thyroid lesions.The patients with hypothyroidism has low TH level , and negative feedback is weak , which can lead to hyper-plasia and hypertrophy of thyroid -stimulating hormone (TSH) cell, high TSH level, pituitary hyperplasia, high prolactin lev-el, and low adrenocorticotropic hormone ( ACTH) and growth hormone ( GH) levels; After thyroid hormone ( such as optimal ) replacement therapy , thyroid function gradually return to normal , then hypertrophic pituitary gland evidently shrink , levels of the prolactin, ACTH, GH and other hormone return to normal.