中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
10期
58-59,60
,共3页
冠心病%阿司匹林%氯吡格雷%可行性%临床疗效
冠心病%阿司匹林%氯吡格雷%可行性%臨床療效
관심병%아사필림%록필격뢰%가행성%림상료효
Coronary heart disease%Aspirin%Clopidogrel%Feasibility%Clinical effect
目的:探讨氯吡格雷联合阿司匹林抗血小板治疗冠心病老年患者的可行性和安全性。方法:选取本院2012年1月-2013年6月收治的老年冠心病患者l00例,按随机数字表法分为观察组和对照组,每组各50例。对照组给予阿司匹林;观察组给予氯吡格雷联合阿司匹林。观察两组的血小板计数、血小板聚集率、出血率及凝血三项。结果:治疗后,两组血小板计数和血小板聚集率较治疗前均明显降低(P<0.05),出血率与治疗前比较差异无统计学意义(P>0.05);两组间血小板计数、出血率比较,差异无统计学意义(P>0.05),但在治疗6个月和12个月时,观察组血小板聚集率疗效优于对照组(P<0.05);两组治疗前后及两组间的凝血三项比较变化均不明显。结论:采用氯吡格雷联合阿司匹林双联疗法疗效治疗老年冠心病患者临床疗效显著,安全可行。
目的:探討氯吡格雷聯閤阿司匹林抗血小闆治療冠心病老年患者的可行性和安全性。方法:選取本院2012年1月-2013年6月收治的老年冠心病患者l00例,按隨機數字錶法分為觀察組和對照組,每組各50例。對照組給予阿司匹林;觀察組給予氯吡格雷聯閤阿司匹林。觀察兩組的血小闆計數、血小闆聚集率、齣血率及凝血三項。結果:治療後,兩組血小闆計數和血小闆聚集率較治療前均明顯降低(P<0.05),齣血率與治療前比較差異無統計學意義(P>0.05);兩組間血小闆計數、齣血率比較,差異無統計學意義(P>0.05),但在治療6箇月和12箇月時,觀察組血小闆聚集率療效優于對照組(P<0.05);兩組治療前後及兩組間的凝血三項比較變化均不明顯。結論:採用氯吡格雷聯閤阿司匹林雙聯療法療效治療老年冠心病患者臨床療效顯著,安全可行。
목적:탐토록필격뢰연합아사필림항혈소판치료관심병노년환자적가행성화안전성。방법:선취본원2012년1월-2013년6월수치적노년관심병환자l00례,안수궤수자표법분위관찰조화대조조,매조각50례。대조조급여아사필림;관찰조급여록필격뢰연합아사필림。관찰량조적혈소판계수、혈소판취집솔、출혈솔급응혈삼항。결과:치료후,량조혈소판계수화혈소판취집솔교치료전균명현강저(P<0.05),출혈솔여치료전비교차이무통계학의의(P>0.05);량조간혈소판계수、출혈솔비교,차이무통계학의의(P>0.05),단재치료6개월화12개월시,관찰조혈소판취집솔료효우우대조조(P<0.05);량조치료전후급량조간적응혈삼항비교변화균불명현。결론:채용록필격뢰연합아사필림쌍련요법료효치료노년관심병환자림상료효현저,안전가행。
Objective:To explore the combination of feasibility and safety of clopidogrel and aspirin antiplatelet therapy for coronary heart disease in elderly patients. Method:100 elderly patients with coronary heart disease in our hospital from January 2012 to June 2013 were randomly divided into observation group and control group ,50 cases in each group . The control group were given aspirin;the observation group were treated with clopidogrel and aspirin. The platelet count,platelet aggregation rate,two groups of hemorrhage and coagulation three were observed. Result:After treatment,platelet count and platelet aggregation rate of two groups significantly decreased compared with those before treatment(P<0.05). Bleeding rate had no significant difference compared with before treatment(P>0.05);there were no significant differences between the two groups about the platelet count,rate of hemorrhage(P>0.05). The platelet count,rate of hemorrhage of the two groups had no significant difference(P>0.05),but the rate of platelet aggregation effect of the observation group was better than the control group after treatment for 6 months and 12 months(P<0.05). In the two groups before and after treatment and between the two groups,changes in three items of blood coagulation were not obvious. Conclusion:The combination double therapy treatment of clopidogrel and aspirin of elderly patients with coronary heart disease is significantly,safe and feasible.