中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2013年
22期
14-15
,共2页
杜登青%曾琼%蔡毓凡%林鑫江
杜登青%曾瓊%蔡毓凡%林鑫江
두등청%증경%채육범%림흠강
苯磺酸氨氯地平%贝那普利%高血压
苯磺痠氨氯地平%貝那普利%高血壓
분광산안록지평%패나보리%고혈압
Amlodipine Besylate%Benazepril%Hypertension
目的:探讨分析苯磺酸氨氯地平联合贝那普利治疗高血压病的临床疗效。方法:选取2010年10月-2012年9月在笔者所在医院内科治疗的高血压病患者112例,随机分为观察组(n=56)和对照组(n=56),对照组给予苯磺酸氨氯地平片口服治疗,观察组给予苯磺酸氨氯地平片口服治疗的基础上加服贝那普利。连续治疗8周后,比较两组患者治疗后疗效、不良反应发生率及治疗前后血压变化情况。结果:治疗后观察组总有效率为91.1%,血压平均值为(126±13)/(81±7)mm Hg,不良反应发生率为3.6%;对照组总有效率为73.2%,血压平均值为(137±14)/(92±10)mm Hg,不良反应发生率为12.5%;两组总有效率、血压平均值及不良反应发生率比较差异具有统计学意义(P<0.05),两组患者治疗前后的血压变化比较差异亦具有统计学意义(P<0.05)。结论:苯磺酸氨氯地平与贝那普利联合治疗高血压,取得单用氨氯地平未能达到的临床疗效,且不良反应比较少,适合在临床上广泛推广运用。
目的:探討分析苯磺痠氨氯地平聯閤貝那普利治療高血壓病的臨床療效。方法:選取2010年10月-2012年9月在筆者所在醫院內科治療的高血壓病患者112例,隨機分為觀察組(n=56)和對照組(n=56),對照組給予苯磺痠氨氯地平片口服治療,觀察組給予苯磺痠氨氯地平片口服治療的基礎上加服貝那普利。連續治療8週後,比較兩組患者治療後療效、不良反應髮生率及治療前後血壓變化情況。結果:治療後觀察組總有效率為91.1%,血壓平均值為(126±13)/(81±7)mm Hg,不良反應髮生率為3.6%;對照組總有效率為73.2%,血壓平均值為(137±14)/(92±10)mm Hg,不良反應髮生率為12.5%;兩組總有效率、血壓平均值及不良反應髮生率比較差異具有統計學意義(P<0.05),兩組患者治療前後的血壓變化比較差異亦具有統計學意義(P<0.05)。結論:苯磺痠氨氯地平與貝那普利聯閤治療高血壓,取得單用氨氯地平未能達到的臨床療效,且不良反應比較少,適閤在臨床上廣汎推廣運用。
목적:탐토분석분광산안록지평연합패나보리치료고혈압병적림상료효。방법:선취2010년10월-2012년9월재필자소재의원내과치료적고혈압병환자112례,수궤분위관찰조(n=56)화대조조(n=56),대조조급여분광산안록지평편구복치료,관찰조급여분광산안록지평편구복치료적기출상가복패나보리。련속치료8주후,비교량조환자치료후료효、불량반응발생솔급치료전후혈압변화정황。결과:치료후관찰조총유효솔위91.1%,혈압평균치위(126±13)/(81±7)mm Hg,불량반응발생솔위3.6%;대조조총유효솔위73.2%,혈압평균치위(137±14)/(92±10)mm Hg,불량반응발생솔위12.5%;량조총유효솔、혈압평균치급불량반응발생솔비교차이구유통계학의의(P<0.05),량조환자치료전후적혈압변화비교차이역구유통계학의의(P<0.05)。결론:분광산안록지평여패나보리연합치료고혈압,취득단용안록지평미능체도적림상료효,차불량반응비교소,괄합재림상상엄범추엄운용。
Objective:To explore and analysis on the effect of hypertension treated by amlodipine besylate with benazepril.Method:Selected 112 hypertensive patients who were treated in internal medicine of our hospital from October in 2010 to September in 2012,and randomly divided them into two groups. The control group(n=56):patients were treated by oral therapy with amlodipine besylate tablets.The observation group(n=56):patients were treated by oral therapy with amlodipine besylate tablets plus benazepril.After 8-weeks continuous treatment,Curative effects the incidence rate of adverse reaction,the changes of blood pressure before and after treatment were compared between the two groups after treatment.Result:After treatment, the total efficiency of the observation group was 91.1%,the average value of blood pressure was(126±13)/(81±7)mm Hg,the incidence of adverse reaction was 3.6%;the total efficiency of the observation group was 73.2%,the average value of blood pressure was(137±14)/(92±10)mm Hg, the incidence of adverse reaction was 12.5%;made a comparison of the total efficiency of two groups,blood pressure mean value and the incidence of adverse reactions were statistically significant(P<0.05),made a comparison of the blood pressure changes before and after treatment,it was statistically significant(P<0.05). Conclusion:For the treatment of the hypertension,the therapy of amlodipine besylate with benazepril get the clinical effects the amlodipine only fail to do with relatively less adverse reaction. So the therapy of hypertension treated by amlodipine besylate with benazepril is suitable for the extensive popularization in clinical application.