CAJ | 학술논문

　　目的：探讨三维适形放疗同期奈达铂化疗治疗局部晚期鼻咽癌近期疗效，为其临床治疗提供可参考依据。方法：连续收集100例入住本院诊断为局部晚期鼻咽癌患者，采用随机数字法平均分为A、B两组，A组患者给予三维适形放疗同期给予奈达铂化疗治疗措施， B组患者给予三维适形放疗同期给予顺铂化疗治疗措施，观察两组患者的近期临床疗效及相关并发症的发生。结果：A组患者完全缓解、部分缓解例数及总有效率明显高于B组患者，两组间比较差异有统计学意义（P<0.05）。A组患者急性不良反应的发生率26.0%，慢性不良反应的发生率74.0%，B组患者急性不良反应的发生率32.0%，慢性不良反应的发生率76.0%，两组间比较差异无统计学意义（P>0.05）。结论：三维适形放疗对治疗局部晚期鼻咽癌有较好的临床疗效，同时辅以予奈达铂化疗治疗临床疗效更好，且其不良反应的发生率未有明显增加，值得临床推广应用。
　　목적：탐토삼유괄형방료동기내체박화료치료국부만기비인암근기료효，위기림상치료제공가삼고의거。방법：련속수집100례입주본원진단위국부만기비인암환자，채용수궤수자법평균분위A、B량조，A조환자급여삼유괄형방료동기급여내체박화료치료조시， B조환자급여삼유괄형방료동기급여순박화료치료조시，관찰량조환자적근기림상료효급상관병발증적발생。결과：A조환자완전완해、부분완해례수급총유효솔명현고우B조환자，량조간비교차이유통계학의의（P<0.05）。A조환자급성불량반응적발생솔26.0%，만성불량반응적발생솔74.0%，B조환자급성불량반응적발생솔32.0%，만성불량반응적발생솔76.0%，량조간비교차이무통계학의의（P>0.05）。결론：삼유괄형방료대치료국부만기비인암유교호적림상료효，동시보이여내체박화료치료림상료효경호，차기불량반응적발생솔미유명현증가，치득림상추엄응용。
Objective:To observe the short-term effect of three-dimensional conformal radiotherapy with concurrent chemotherapy for locally advanced nasopharyngeal carcinoma.Method:Continuously collected 100 cases in our hospital diagnosed with locally advanced nasopharyngeal carcinoma patients with digital method adopted randomly divided into A,B two groups,group A patients were given three-dimensional conformal radiation therapy, at the same time gave nida’s platinum chemotherapy treatment,B group patients were given three-dimensional conformal radiation therapy,at the same time gave cisplatin chemotherapy treatment,observed two groups of patients with recent clinical efficacy and related complications. Result:The cases of complete response,partial response and the total effective rate in group A patients were significantly higher than that of group B patients,total effective rate was 86.0%and 68.0%respectively,comparing difference between the two groups was statistically significant(P<0.05). The incidence of adverse reactions in patients with group A,26.0%chronic adverse reaction rate of 74.0%,the incidence of adverse reactions in patients with group B 32.0%, chronic 76.0%incidence of adverse reactions,there was no statistically significant difference between the two groups(P>0.05).Conclusion:Three-dimensional conformal radiotherapy for locally advanced nasopharyngeal carcinoma has better clinical curative effect,at the same time complementary with chemotherapy treatment clinical curative effect is better,and the incidence of adverse reactions did not significantly increase,it is worthy of clinical popularization and application.