CAJ | 학술논문

　　目的：研究肺结核患者合并乙肝病毒感染与发生药物性肝炎的病因关系。方法：采用前瞻性队列分析的研究方法，以2009年10月1日-2012年2月1日期间就诊的合并乙肝病毒感染的87例肺结核患者作为暴露组，单纯肺结核患者作为对照组，随访在抗结核治疗中的药物性肝炎发生的情况。对照组的选择采用内对照，随机1：1配对的原则。结果：合并慢性乙肝的肺结核患者发生药物性肝炎的发病率为30.8%，高于对照组的10.7%，两组间差异有统计学意义（x2=10.336，P<0.05）。相对危险度为2.9（x2=10.28），95%置信区间是（1.51，5.55）。两组患者在转氨酶水平、重度肝炎发病率和需要调整用药的比例方面差异无统计学意义（P>0.05）。结论：乙肝病毒感染是肺结核患者发生药物性肝炎的病因之一，这类患者在密切监测下仍可以耐受标准治疗方案。
　　목적：연구폐결핵환자합병을간병독감염여발생약물성간염적병인관계。방법：채용전첨성대렬분석적연구방법，이2009년10월1일-2012년2월1일기간취진적합병을간병독감염적87례폐결핵환자작위폭로조，단순폐결핵환자작위대조조，수방재항결핵치료중적약물성간염발생적정황。대조조적선택채용내대조，수궤1：1배대적원칙。결과：합병만성을간적폐결핵환자발생약물성간염적발병솔위30.8%，고우대조조적10.7%，량조간차이유통계학의의（x2=10.336，P<0.05）。상대위험도위2.9（x2=10.28），95%치신구간시（1.51，5.55）。량조환자재전안매수평、중도간염발병솔화수요조정용약적비례방면차이무통계학의의（P>0.05）。결론：을간병독감염시폐결핵환자발생약물성간염적병인지일，저류환자재밀절감측하잉가이내수표준치료방안。
Objective:To study the exposure-effect relationship between the pulmonary tuberculosis patients(PTB)co-infected with hepatitis B virus(HBV)and drug-induced hepatitis(DIH). Method:A prospective cohort study was conducted. A total of 87 co-infected cases newly diagnosed during the period from Oct 2009 to Feb 2012 were arranged to the exposure group(TB-HBV),while the same quantity cases were selected into the control group(TB)according to randomizing and 1:1 pair matching. Both groups patients were treated by first-line antituberculosis drugs and followed up the liver function. The datum were analyzed by SPSS 11.0.Result:The incidence rate of DIH in the exposure group was 30.8%,which was significantly higher than that in the controls 10.7%(x 2=10.336,P<0.05).Relative risk value was 2.9(x2=10.28),95%CI:1.51,5.55. Although higher transaminase level,more severe DIH and cases who needed to alternate or discontinue the regimens were observed among the TB-HBV,there were no significant difference between the two groups(P>0.05).Conclusion:HBV co-infection is one of the cause of DIH in the PTB.The co-infected patients can be treated by the standard short-course regimens with watching out of the liver function.