CAJ | 학술논문

　　目的：观察慢性肺心病急性加重期患者与慢阻肺急性加重期患者治疗前后动脉血气分析、血浆脑钠肽（ BNP）和血浆D-二聚体、血液流变学的变化，探讨其与肺心病病情严重程度及疗效的相关性。方法：25例慢性肺心病急性加重期患者与26例慢阻肺急性加重期患者给予2周的综合治疗。治疗前后分别测定动脉血气分析、血浆BNP和D-二聚
　　목적：관찰만성폐심병급성가중기환자여만조폐급성가중기환자치료전후동맥혈기분석、혈장뇌납태（ BNP）화혈장D-이취체、혈액류변학적변화，탐토기여폐심병병정엄중정도급료효적상관성。방법：25례만성폐심병급성가중기환자여26례만조폐급성가중기환자급여2주적종합치료。치료전후분별측정동맥혈기분석、혈장BNP화D-이취
Objective:To observe the variation of arterial blood gases , plasma brain natriuretic peptide (BNP ) and plasma D-dimer levels and hemorheology in patients with either acute exacerbation of chronic pulmo -nary heart disease or acute exacerbations of chronic obstructive pulmonary disease( AECOPD ) before and after medication for assessing the condi-tions and therapeutic effects.Methods:Patients with acute exacerbation of chronic cor pulmonale(n=25) and AECOPD(n =26) underwent com-prehensive therapy for consecutive 2 weeks.The arterial blood gas ( PaO2 and PaCO2 ) analysis was performed, and the concentration of plasma BNP and plasma D-dimer as well as the hemorheological indexes were de-termined and compared before and after treatment .Results:Significant ab-normal levels of arterial PaO2 and PaCO2,plasma BNP and plasma and variation of hemorheological indexes were seen in patients with acute ex -acerbation of chronic pulmonary heart disease,suggesting that these indi-cators were associated with severity of the conditions .After two weeks of medication,the previous indicators were improved significantly ,which had statistical difference(P <0.01).Plasma BNP and D-dimer levels were negatively correlated with arterial PaO 2(P<0.05 ),yet positively with ar-terial PaCO2 and whole blood viscosity,particularly with plasma viscosity (P<0.05).Conclusion:The levels of plasma BNP and D-dimer may serve as indicators for estimation of the severity of acute exacerbation of chronic pulmonary disease and its curative outcomes.