CAJ | 학술논문

目的：探讨孕期服用抗精神病药物的安全性。方法：对150例患有精神分裂症且服用抗精神病药物进行治疗的妊娠期患者的分娩年龄、精神病遗传史、使用药物情况、新生儿状况进行随访，并对其进行统计学处理。结果：新生儿有缺陷的为26例，约占17.3%；分娩年龄、精神病阳性遗传史等均无明显差异，不具有统计学意义(P〉0.05)；新生儿缺陷与妊娠期间用药剂量有关，具有统计学意义(P〈0.05)；抗精神病药物中氯丙嗪对胎儿的不良影响最大。结论：孕妇妊娠期间不宜服用药物，情况严重者应减少用药；抗精神病药物在合理范围内对胎儿影响较小，达到一定剂量后对胎儿不良影响较大，致死，畸形发生率较高；若坚持服用药物则应终止妊娠。
목적：탐토잉기복용항정신병약물적안전성。방법：대150례환유정신분렬증차복용항정신병약물진행치료적임신기환자적분면년령、정신병유전사、사용약물정황、신생인상황진행수방，병대기진행통계학처리。결과：신생인유결함적위26례，약점17.3%；분면년령、정신병양성유전사등균무명현차이，불구유통계학의의(P〉0.05)；신생인결함여임신기간용약제량유관，구유통계학의의(P〈0.05)；항정신병약물중록병진대태인적불량영향최대。결론：잉부임신기간불의복용약물，정황엄중자응감소용약；항정신병약물재합리범위내대태인영향교소，체도일정제량후대태인불량영향교대，치사，기형발생솔교고；약견지복용약물칙응종지임신。
To investigate the safety of pregnancy taking antipsychotics. Methods:150 patients of childbearing age with schizophrenia taking antipsychotic treatment, and the patient's pregnancy, genetic history of mental il ness, drug use, the condition of the newborn fol ow-up, and its statistical treatment. Results:The newborn is defective in 26 cases, accounting for 17. 3%; childbirth age, positive genetic history of mental il ness, such as no significant dif erence was not statistical y significant (P> 0. 05);birth defects during pregnancy and dose related, sta-tistical y significant (P <0. 05);antipsychotic chlorpromazine adverse ef ects on the fetus maximum. Conclusions:During pregnancy, pregnant women should not take the drug, serious cases should be reduced by medication;antipsychotic drugs within a reasonable range of less impact on the fetus, after reaching a certain dose greater adverse ef ects on the fetus, death, a higher inci-dence of malformations;insist medication should terminate the pregnancy.