国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2014年
5期
885-887
,共3页
干眼症%人工泪液%小牛血清去蛋白提取物眼用凝胶
榦眼癥%人工淚液%小牛血清去蛋白提取物眼用凝膠
간안증%인공루액%소우혈청거단백제취물안용응효
dry eye%artificial tears%deproteinated extract of calf blood ophthalmic gel
目的：观察小牛血清去蛋白提取物眼用凝胶联合人工泪液局部滴眼治疗干眼症的临床疗效。<br> 方法：将符合干眼症诊断标准的150例300眼机分为治疗组和对照组,各75例150眼。治疗组采用局部滴用小牛血清去蛋白提取物眼用凝胶和右旋糖酐羟丙纤维素滴眼液治疗；对照组采用单纯滴用右旋糖酐羟丙纤维素滴眼液治疗。根据临床症状和基础泪液分泌试验、泪膜破裂时间、角膜荧光素钠染色等检查进行评分,以及泪液蛋白进行测定,治疗观察3 mo。<br> 结果：两组治疗后泪膜破裂时间( breaking up time,BUT),基础泪液分泌试验( SchirmerⅠtest,SⅠt),角膜荧光素染色与治疗前比较,差异均有统计学意义( P<0.05或P<0.01),且治疗后治疗组上述指标变化程度明显优于对照组(P<0.05)；治疗组总有效率96%,对照组总有效率75%,治疗组疗效明显优于对照组(P<0.05)。治疗组治疗后泪液蛋白含量明显提高(P<0.05)。<br> 结论：小牛血清去蛋白提取物眼用凝胶联合人工泪液局部点眼治疗干眼症疗效较单纯使用人工泪液滴眼疗效好。
目的：觀察小牛血清去蛋白提取物眼用凝膠聯閤人工淚液跼部滴眼治療榦眼癥的臨床療效。<br> 方法：將符閤榦眼癥診斷標準的150例300眼機分為治療組和對照組,各75例150眼。治療組採用跼部滴用小牛血清去蛋白提取物眼用凝膠和右鏇糖酐羥丙纖維素滴眼液治療；對照組採用單純滴用右鏇糖酐羥丙纖維素滴眼液治療。根據臨床癥狀和基礎淚液分泌試驗、淚膜破裂時間、角膜熒光素鈉染色等檢查進行評分,以及淚液蛋白進行測定,治療觀察3 mo。<br> 結果：兩組治療後淚膜破裂時間( breaking up time,BUT),基礎淚液分泌試驗( SchirmerⅠtest,SⅠt),角膜熒光素染色與治療前比較,差異均有統計學意義( P<0.05或P<0.01),且治療後治療組上述指標變化程度明顯優于對照組(P<0.05)；治療組總有效率96%,對照組總有效率75%,治療組療效明顯優于對照組(P<0.05)。治療組治療後淚液蛋白含量明顯提高(P<0.05)。<br> 結論：小牛血清去蛋白提取物眼用凝膠聯閤人工淚液跼部點眼治療榦眼癥療效較單純使用人工淚液滴眼療效好。
목적：관찰소우혈청거단백제취물안용응효연합인공루액국부적안치료간안증적림상료효。<br> 방법：장부합간안증진단표준적150례300안궤분위치료조화대조조,각75례150안。치료조채용국부적용소우혈청거단백제취물안용응효화우선당항간병섬유소적안액치료；대조조채용단순적용우선당항간병섬유소적안액치료。근거림상증상화기출루액분비시험、루막파렬시간、각막형광소납염색등검사진행평분,이급루액단백진행측정,치료관찰3 mo。<br> 결과：량조치료후루막파렬시간( breaking up time,BUT),기출루액분비시험( SchirmerⅠtest,SⅠt),각막형광소염색여치료전비교,차이균유통계학의의( P<0.05혹P<0.01),차치료후치료조상술지표변화정도명현우우대조조(P<0.05)；치료조총유효솔96%,대조조총유효솔75%,치료조료효명현우우대조조(P<0.05)。치료조치료후루액단백함량명현제고(P<0.05)。<br> 결론：소우혈청거단백제취물안용응효연합인공루액국부점안치료간안증료효교단순사용인공루액적안료효호。
AIM: To observe the efficacy of deproteinated extract of calf blood ophthalmic gel with artificial tears local eye drops in treatment of dry eye. <br> METHODS: A randomized, parallel-control approach was adopted, 150 patients (300 eyes) with dry eye were divided into treatment group and control group equally (75 cases, 150 eyes). The treatment group was applied Dextran and Hypromellose eye drops combined with deproteinated extract of calf blood ophthalmic gel, simply Dextran and Hypromellose eye drops for control group. Clinical symptoms, SchirmerⅠ test ( SⅠt ) , break-up time ( BUT ) , corneal fluorescein staining and tear protein were observed. Therapeutic observation was 3mo. <br> RESULTS:BUT, SⅠt, and corneal fluorescein staining have statistical significance before and after treatment( P<0. 05 or P<0. 01), the changes in treatment group were obviously superior to that in control group (P<0. 05). The total clinical effect satisfaction rates were 96% for treatment group and 75% for control group, curative effect in treatment group was obviously superior to control group (P<0. 05). Tear protein was significantly improved in treatment group(P<0. 05). <br> CONCLUSION: The deproteinated extract of calf blood ophthalmic gel with artificial tears local eye drops perform better than artificial tears eye drops only in treatment of dry eye.
