中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2014年
10期
1133-1135,1139
,共4页
结直肠肿瘤%肿瘤间质%细胞外基质%预后
結直腸腫瘤%腫瘤間質%細胞外基質%預後
결직장종류%종류간질%세포외기질%예후
Colorectal neoplasms%Tumor stroma%Extracellular matrix%Prognosis
目的:探讨肿瘤间质比例( SP)与结直肠癌病理特征及患者预后的关系。方法应用图像分析软件计算我院病理科2009-2012年存档的121例石蜡包埋结直肠癌手术切除标本HE染色切片中肿瘤间质面积占切片面积的比例,采用χ2检验等方法分析其与肿瘤临床病理特征的关联,结合随访资料利用生存函数分析其与患者预后的关系。结果结直肠癌组织平均SP为(45.8±17.3)%,符合正态分布。将SP≥50%定为间质高比例,<50%定为间质低比例,间质高比例肿瘤占所有肿瘤的32.2%(39/121);间质高比例与低比例肿瘤在浸润深度、肿瘤复发/转移上差异有统计学意义( P<0.05),而在患者年龄、性别、部位、组织学分级、淋巴结转移及TNM分期上差异无统计学意义( P>0.05)。间质高比例患者无进展生存时间比低比例患者短(中位生存时间29.2个月比34.3个月),差异有统计学意义( P=0.045);总生存时间亦短(中位生存时间33.5个月比36.8个月),但差异无统计学意义( P=0.078)。结论结直肠癌组织中SP呈正态分布,间质高比例与肿瘤浸润范围广及患者无进展生存时间短密切相关,可能是结直肠癌独立的预后因子。
目的:探討腫瘤間質比例( SP)與結直腸癌病理特徵及患者預後的關繫。方法應用圖像分析軟件計算我院病理科2009-2012年存檔的121例石蠟包埋結直腸癌手術切除標本HE染色切片中腫瘤間質麵積佔切片麵積的比例,採用χ2檢驗等方法分析其與腫瘤臨床病理特徵的關聯,結閤隨訪資料利用生存函數分析其與患者預後的關繫。結果結直腸癌組織平均SP為(45.8±17.3)%,符閤正態分佈。將SP≥50%定為間質高比例,<50%定為間質低比例,間質高比例腫瘤佔所有腫瘤的32.2%(39/121);間質高比例與低比例腫瘤在浸潤深度、腫瘤複髮/轉移上差異有統計學意義( P<0.05),而在患者年齡、性彆、部位、組織學分級、淋巴結轉移及TNM分期上差異無統計學意義( P>0.05)。間質高比例患者無進展生存時間比低比例患者短(中位生存時間29.2箇月比34.3箇月),差異有統計學意義( P=0.045);總生存時間亦短(中位生存時間33.5箇月比36.8箇月),但差異無統計學意義( P=0.078)。結論結直腸癌組織中SP呈正態分佈,間質高比例與腫瘤浸潤範圍廣及患者無進展生存時間短密切相關,可能是結直腸癌獨立的預後因子。
목적:탐토종류간질비례( SP)여결직장암병리특정급환자예후적관계。방법응용도상분석연건계산아원병이과2009-2012년존당적121례석사포매결직장암수술절제표본HE염색절편중종류간질면적점절편면적적비례,채용χ2검험등방법분석기여종류림상병리특정적관련,결합수방자료이용생존함수분석기여환자예후적관계。결과결직장암조직평균SP위(45.8±17.3)%,부합정태분포。장SP≥50%정위간질고비례,<50%정위간질저비례,간질고비례종류점소유종류적32.2%(39/121);간질고비례여저비례종류재침윤심도、종류복발/전이상차이유통계학의의( P<0.05),이재환자년령、성별、부위、조직학분급、림파결전이급TNM분기상차이무통계학의의( P>0.05)。간질고비례환자무진전생존시간비저비례환자단(중위생존시간29.2개월비34.3개월),차이유통계학의의( P=0.045);총생존시간역단(중위생존시간33.5개월비36.8개월),단차이무통계학의의( P=0.078)。결론결직장암조직중SP정정태분포,간질고비례여종류침윤범위엄급환자무진전생존시간단밀절상관,가능시결직장암독립적예후인자。
Objective To investigate the relationship between stroma portion and the clinicopathologic features of colo -rectal cancer and patients′prognosis.Methods The image analysis software was used to measure the proportion of the stroma per-centage ( SP) in colorectal cancer routine HE stained histological sections of 121 samples archived in the department of pathology between 2009 and 2012.The association between SP and clinicopathologic variables was accessed by χ2 test.Survival function com-bined with follow-up data was used to analyze the relationship between SP and patients′prognosis.Results Of 121 analyzed samples, the mean of SP in the colorectal cancer tissues , which followed normal distribution , was 45.8% ±17.3%.39 ( 32.2%) of them had a high SP based on the cutoff value of 50%.The difference in depth of invasion and tumor recurrence /me-tastasis between high SP and low SP had statistical significance (P<0.05) and the differences in age, gender, location, histo-logical grade , Lymph Node Metastasis and TNM stage were not significant ( P>0.05 ) .High SP was associated with poor pro-gression free survival significantly (median survival time was 29.2 months vs 34.3 months) (P=0.045) .High SP was also as-sociated with shortest overall survival but insignificantly (median survival time was 33.5 months vs 36.8 months) (P=0.078). Conclusion The SP presents normal distribution in colorectal carcinoma tissues.High SP was significantly associated with inva-sion depth and poorer prognosis of colorectal cancer patients , thus may be applied as an independent prognosis factor in colorectal carcinoma.