中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2014年
10期
1172-1175,1179
,共5页
单核细胞趋化蛋白-1%基因多态性%狼疮性肾炎%Meta分析
單覈細胞趨化蛋白-1%基因多態性%狼瘡性腎炎%Meta分析
단핵세포추화단백-1%기인다태성%랑창성신염%Meta분석
Monocyte chemoattractant protein -1%Polymorphism%Lupus nephritis%Meta-analysis
目的:探讨单核细胞趋化蛋白-1(MCP-1)启动子-2518 A/G位点基因多态性与狼疮性肾炎(LN)的关系。方法通过检索PubMed、 Embase、 The web of science、中国学术期刊网全文数据库( CNKI)、万方科技期刊全文数据库、中国生物医学数据库( CBM),收集所有MCP-1启动子-2518 A/G位点基因多态性与LN易患性的病例对照研究,按纳入排除标准并进行质量评价后,提取有效数据进行Meta分析。结果共纳入11项研究,其中共包括LN患者989名,健康对照者1935名,采用共显性模型对结果进行分析。 GG/AA、 GG/AG、 AG/AA三组基因型合并后的OR 值分别为1.60〔95%CI (1.00,2.59), P =0.052〕、1.34〔95%CI (1.06,1.70), P =0.015〕、1.28〔95%CI (0.94,1.94), P=0.120〕,等位基因G/A合并后的OR值是1.32〔95%CI (1.04,1.66), P=0.020〕,其中GG/AG、 G/A组差异有统计学意义。亚组分析显示,在美洲人群中, MCP-1启动子-2518 A/G位点基因多态性与LN存在很强的相关性,而在亚洲及欧洲人群中,还没有发现二者的相关性。结论在美洲人群中, MCP-1启动子-2518 A/G位点基因多态性与LN的发生相关,而在亚洲和欧洲人群中,尚不能得出同样的结论。
目的:探討單覈細胞趨化蛋白-1(MCP-1)啟動子-2518 A/G位點基因多態性與狼瘡性腎炎(LN)的關繫。方法通過檢索PubMed、 Embase、 The web of science、中國學術期刊網全文數據庫( CNKI)、萬方科技期刊全文數據庫、中國生物醫學數據庫( CBM),收集所有MCP-1啟動子-2518 A/G位點基因多態性與LN易患性的病例對照研究,按納入排除標準併進行質量評價後,提取有效數據進行Meta分析。結果共納入11項研究,其中共包括LN患者989名,健康對照者1935名,採用共顯性模型對結果進行分析。 GG/AA、 GG/AG、 AG/AA三組基因型閤併後的OR 值分彆為1.60〔95%CI (1.00,2.59), P =0.052〕、1.34〔95%CI (1.06,1.70), P =0.015〕、1.28〔95%CI (0.94,1.94), P=0.120〕,等位基因G/A閤併後的OR值是1.32〔95%CI (1.04,1.66), P=0.020〕,其中GG/AG、 G/A組差異有統計學意義。亞組分析顯示,在美洲人群中, MCP-1啟動子-2518 A/G位點基因多態性與LN存在很彊的相關性,而在亞洲及歐洲人群中,還沒有髮現二者的相關性。結論在美洲人群中, MCP-1啟動子-2518 A/G位點基因多態性與LN的髮生相關,而在亞洲和歐洲人群中,尚不能得齣同樣的結論。
목적:탐토단핵세포추화단백-1(MCP-1)계동자-2518 A/G위점기인다태성여랑창성신염(LN)적관계。방법통과검색PubMed、 Embase、 The web of science、중국학술기간망전문수거고( CNKI)、만방과기기간전문수거고、중국생물의학수거고( CBM),수집소유MCP-1계동자-2518 A/G위점기인다태성여LN역환성적병례대조연구,안납입배제표준병진행질량평개후,제취유효수거진행Meta분석。결과공납입11항연구,기중공포괄LN환자989명,건강대조자1935명,채용공현성모형대결과진행분석。 GG/AA、 GG/AG、 AG/AA삼조기인형합병후적OR 치분별위1.60〔95%CI (1.00,2.59), P =0.052〕、1.34〔95%CI (1.06,1.70), P =0.015〕、1.28〔95%CI (0.94,1.94), P=0.120〕,등위기인G/A합병후적OR치시1.32〔95%CI (1.04,1.66), P=0.020〕,기중GG/AG、 G/A조차이유통계학의의。아조분석현시,재미주인군중, MCP-1계동자-2518 A/G위점기인다태성여LN존재흔강적상관성,이재아주급구주인군중,환몰유발현이자적상관성。결론재미주인군중, MCP-1계동자-2518 A/G위점기인다태성여LN적발생상관,이재아주화구주인군중,상불능득출동양적결론。
Objective The purpose of this study is to explore whether the monocyte chemoattractant protein -1 (MCP-1) promoter -2518 A/G polymorphism confers susceptibility to lupus nephritis (LN) .Methods Literature search of PubMed, Embase, Web of Science, CNKI, Wanfang and CBM databases was conducted on studies about the correlation be -tween MCP-1 promoter -2518 A/G gene polymorphisms and lupus nephritis.All the cases involved were brought into control study and after quality evaluation the effective data were extracted for Meta analysis.Results Eleven studies ( including 989 LN patients and 1 935 controls ) were included in our meta -analysis.Co -dominant model was used to analyze the results.The pooled OR (95%CI) of GG/AA, GG/AG, AG/AA were 1.60 〔95%CI (1.00, 2.59), P =0.052〕, 1.34 〔95%CI (1.06, 1.70), P=0.015〕, 1.28 〔95%CI (0.94, 1.94), P=0.120〕 and the pooled OR (95%CI) of G/A was 1.32〔95%CI (1.04, 1.66), P=0.020〕 individually, statistical differences were existed in GG/AG and G/A.Subgroup analysis indicated MCP-1 promoter -2518 A/G polymorphism had strong correlation with lupus nephritis in the people of Americas, but no similar correlation in the people of Asia and Europe .Conclusion The author suggests among American people , MCP-1 pro-moter -2518 A/G polymorphism may play a role in the occurrence of lupus nephritis , however it is not true of Asian and Europe-an population.