CAJ | 학술논문

胰腺癌恶性度高、预后差、死亡率高，临床通常依靠影像检测，所用诊断试剂盒特异性、准确性低，使其早期发现、鉴别诊断困难。分子诊断学是近年来新发展的临床诊断手段之一。由于miRNA在胰腺癌中的特异性表达使其可以作为胰腺癌的新型诊断标志物，其相关的检测技术也因此得到不断发展。本文综述了胰腺癌当前临床诊断方法及诊断标志物，并对用于胰腺癌miRNA早期检测方法进行了探究。
이선암악성도고、예후차、사망솔고，림상통상의고영상검측，소용진단시제합특이성、준학성저，사기조기발현、감별진단곤난。분자진단학시근년래신발전적림상진단수단지일。유우miRNA재이선암중적특이성표체사기가이작위이선암적신형진단표지물，기상관적검측기술야인차득도불단발전。본문종술료이선암당전림상진단방법급진단표지물，병대용우이선암miRNA조기검측방법진행료탐구。
Pancreatic cancer is a malignant tumor with poor prognosis and extremely high mortality.Its diagnosis mainly relies on clinical imaging.Current diagnostic kits for pancreatic cancer diagnosis have the disadvantages of low specificity and accuracy,which results the poor early detection and diagnosis.In recent years,molecular diagnostics has been one of newly developing clinical diagnostic means.miRNA is abnormally expressed in pancreatic cancer,and it can become a novel tumor marker.The miRNA detection technology has developed continuously.This paper aims to review the current clinical diagnosis and diagnostic markers for pancreatic cancer and explore some methods used in the early detection of miRNA for pancreatic cancer.