湖南师范大学学报(医学版)
湖南師範大學學報(醫學版)
호남사범대학학보(의학판)
JOURNAL OF HUNAN NORMAL UNIVERSITY(MEDICAL SCIENCE)
2013年
3期
82-84,87
,共4页
厉娟%钟礼立%杨坤云
厲娟%鐘禮立%楊坤雲
려연%종례립%양곤운
支原体肺炎%人β防御素-3%肺泡灌洗液
支原體肺炎%人β防禦素-3%肺泡灌洗液
지원체폐염%인β방어소-3%폐포관세액
Mycoplasma pneumoniae pneumonia%human beta-defensin-3%bronchoalveolar lavage fluid
目的:观察肺炎支原体肺炎(MPP)患儿肺泡灌洗液中hBD-3蛋白含量的变化,探讨气道先天性防御机制在肺炎支原体肺炎中的作用。方法:用ELISA测定比较MPP患儿、非MPP患儿以及对照组肺泡灌洗液(BALF)中hBD-3蛋白含量。结果:β-防御素3在MPP患者BALF中蛋白水平较对照组低,但高于非MPP患者。结论:MPP患儿在感染后造成机体免疫损伤,hBD-3表达下降。
目的:觀察肺炎支原體肺炎(MPP)患兒肺泡灌洗液中hBD-3蛋白含量的變化,探討氣道先天性防禦機製在肺炎支原體肺炎中的作用。方法:用ELISA測定比較MPP患兒、非MPP患兒以及對照組肺泡灌洗液(BALF)中hBD-3蛋白含量。結果:β-防禦素3在MPP患者BALF中蛋白水平較對照組低,但高于非MPP患者。結論:MPP患兒在感染後造成機體免疫損傷,hBD-3錶達下降。
목적:관찰폐염지원체폐염(MPP)환인폐포관세액중hBD-3단백함량적변화,탐토기도선천성방어궤제재폐염지원체폐염중적작용。방법:용ELISA측정비교MPP환인、비MPP환인이급대조조폐포관세액(BALF)중hBD-3단백함량。결과:β-방어소3재MPP환자BALF중단백수평교대조조저,단고우비MPP환자。결론:MPP환인재감염후조성궤체면역손상,hBD-3표체하강。
Objective To observe the differential expression of human beta-defensin-3 (hBD-3) protein in mycoplasma pneumoniae pneumonia (MPP) patients and explore the role of defense mechanisms of innate airway in MPP. Methods Use ELISA to detected and compared protein concentration of hBD-3 in MPP patients, non-MPP patients and control. Results protein concentration of hBD-3 in MPP is lower than control but higher than non-MPP patients. Conclusion After MPP infection, immune system would be injured. Expression of hBD-3 was down-regulated.