CAJ | 학술논문

目的：探讨喹硫平治疗老年期痴呆精神行为障碍的临床疗效。方法：80例老年期痴呆精神行为障碍患者，随机分为对照组和观察组两组。对照组患者给予利培酮治疗，观察组患者给予喹硫平治疗。结果：治疗2周、4周、8周后，观察组患者BEHAVE-AD评分均低于治疗前，差异具有统计学意义(P<0.01)；治疗2周、4周、8周后，观察组患者BEHAVE-AD评分均低于对照组，差异具有统计学意义(P<0.01)。观察组患者不良反应发生率12.50%少于对照组不良反应发生率55.00%，差异具有统计学意义(P<0.01)。结论：应用喹硫平治疗老年期痴呆精神行为障碍疗效确切，且安全可靠，临床应用价值显著。
목적：탐토규류평치료노년기치태정신행위장애적림상료효。방법：80례노년기치태정신행위장애환자，수궤분위대조조화관찰조량조。대조조환자급여리배동치료，관찰조환자급여규류평치료。결과：치료2주、4주、8주후，관찰조환자BEHAVE-AD평분균저우치료전，차이구유통계학의의(P<0.01)；치료2주、4주、8주후，관찰조환자BEHAVE-AD평분균저우대조조，차이구유통계학의의(P<0.01)。관찰조환자불량반응발생솔12.50%소우대조조불량반응발생솔55.00%，차이구유통계학의의(P<0.01)。결론：응용규류평치료노년기치태정신행위장애료효학절，차안전가고，림상응용개치현저。
Objective:To explore effects of quetiapine in treatment of senile dementia with the mental and behavioral disorders. Methods:80 senile dementia patients with the mental and behavioral disorders were randomly divided into control group and observation group. The cases in control group were given risperidone, whereas those in observation group was treated with quetiapine. Results:2, 4 and 8 weeks after the treatment, the BEHAVE-AD score of observation group was lower than that before the treatment, and the difference was statistically significant (P<0. 01). 2 weeks, 4 weeks, 8 weeks after the treatment, the BEHAVE-AD score of observa-tion group was lower than that of control group, and the difference was statistically significant (P<0. 01). The incidence of adverse re-actions of the observation group (12. 50%) was lower than that of control group (55. 00%), and the difference was statistically signif-icant (P<0. 01). Conclusions:Quetiapine in the treatment of senile dementia with the mental and behavioral disorders has good cura-tive effect and high safety and reliability, and the value of clinical application is significant.