中华眼视光学与视觉科学杂志
中華眼視光學與視覺科學雜誌
중화안시광학여시각과학잡지
CHINESE JOURNAL OF OPTOMETRY OPHTHALMOLOGY AND VISUAL SCIENCE
2014年
6期
354-358
,共5页
沈梅晓%彭梅%姬戎媛%许哲%荆树栋%马庆凯%吕帆%姜珺
瀋梅曉%彭梅%姬戎媛%許哲%荊樹棟%馬慶凱%呂帆%薑珺
침매효%팽매%희융원%허철%형수동%마경개%려범%강군
体层摄影术,光学相干%圆锥角膜%角膜厚度%重复性与再现性
體層攝影術,光學相榦%圓錐角膜%角膜厚度%重複性與再現性
체층섭영술,광학상간%원추각막%각막후도%중복성여재현성
Tomography,optical coherence%Keratoconus%Corneal thickness%Repeatability and reproducibility
目的 探讨长扫描深度谱域OCT(UL-OCT)测量圆锥角膜患者的全角膜三维厚度分布的重复性与再现性.方法 前瞻性研究.选取圆锥角膜患者10例(10眼),使用自行搭建的UL-OCT获得角膜的横断面图像,采用以角膜顶点为中心进行均等放射状B型扫描获取三维图像.通过全自动分割算法获取10 mm直径范围角膜厚度分布图,并将测量结果与Pentacam 三维眼前节分析诊断系统进行对比.2个仪器的重复性与再现性通过重复性系数与再现性系数(CoR)、组内相关系数(ICC)和变异系数(CV)进行比较.2个仪器的一致性通过配对t检验和Bland-Ahman方法进行分析.结果 对于圆锥角膜患者,UL-OCT测量值的重复性系数为3.43～4.31 μm,再现性系数为3.58～8.10 μm.重复性和再现性的组内相关系数分别为0.998和0.995以上.Pentacam测量值的重复性系数为8.63～14.30 μm,再现性系数为14.59～19.17 μm.重复性和再现性的组内相关系数分别为0.997和0.994以上.UL-OCT系统测量的角膜厚度在中央区、旁中央区、过渡区、周围区分别为(468.9 ±38.6) μm、(482.5 ±48.6) μm、(515.5 ±57.0)μm、(588.0±52.5)μm.Pentacam系统测量的各区角膜厚度分别为(500.9±50.0) μm、(533.9±49.7)μm、(587.9±60.6) μm、(635.3±62.0) μm.Bland-Ahman分析角膜厚度测量结果显示,2种仪器测量结果差值的95％一致性界限在中央区、旁中央区、过渡区分别为-44.49～108.59 μm、-7.47～110.23 μm、-13.21～131.68 μm.结论 在测量圆锥角膜患者全角膜厚度时,与Pentacam系统相比,UL-OCT系统具有更好的重复性和再现性.UL-OCT系统与Pentacam系统得到的角膜厚度测量结果存在差异,因此2种仪器在临床应用时不可互换.
目的 探討長掃描深度譜域OCT(UL-OCT)測量圓錐角膜患者的全角膜三維厚度分佈的重複性與再現性.方法 前瞻性研究.選取圓錐角膜患者10例(10眼),使用自行搭建的UL-OCT穫得角膜的橫斷麵圖像,採用以角膜頂點為中心進行均等放射狀B型掃描穫取三維圖像.通過全自動分割算法穫取10 mm直徑範圍角膜厚度分佈圖,併將測量結果與Pentacam 三維眼前節分析診斷繫統進行對比.2箇儀器的重複性與再現性通過重複性繫數與再現性繫數(CoR)、組內相關繫數(ICC)和變異繫數(CV)進行比較.2箇儀器的一緻性通過配對t檢驗和Bland-Ahman方法進行分析.結果 對于圓錐角膜患者,UL-OCT測量值的重複性繫數為3.43～4.31 μm,再現性繫數為3.58～8.10 μm.重複性和再現性的組內相關繫數分彆為0.998和0.995以上.Pentacam測量值的重複性繫數為8.63～14.30 μm,再現性繫數為14.59～19.17 μm.重複性和再現性的組內相關繫數分彆為0.997和0.994以上.UL-OCT繫統測量的角膜厚度在中央區、徬中央區、過渡區、週圍區分彆為(468.9 ±38.6) μm、(482.5 ±48.6) μm、(515.5 ±57.0)μm、(588.0±52.5)μm.Pentacam繫統測量的各區角膜厚度分彆為(500.9±50.0) μm、(533.9±49.7)μm、(587.9±60.6) μm、(635.3±62.0) μm.Bland-Ahman分析角膜厚度測量結果顯示,2種儀器測量結果差值的95％一緻性界限在中央區、徬中央區、過渡區分彆為-44.49～108.59 μm、-7.47～110.23 μm、-13.21～131.68 μm.結論 在測量圓錐角膜患者全角膜厚度時,與Pentacam繫統相比,UL-OCT繫統具有更好的重複性和再現性.UL-OCT繫統與Pentacam繫統得到的角膜厚度測量結果存在差異,因此2種儀器在臨床應用時不可互換.
목적 탐토장소묘심도보역OCT(UL-OCT)측량원추각막환자적전각막삼유후도분포적중복성여재현성.방법 전첨성연구.선취원추각막환자10례(10안),사용자행탑건적UL-OCT획득각막적횡단면도상,채용이각막정점위중심진행균등방사상B형소묘획취삼유도상.통과전자동분할산법획취10 mm직경범위각막후도분포도,병장측량결과여Pentacam 삼유안전절분석진단계통진행대비.2개의기적중복성여재현성통과중복성계수여재현성계수(CoR)、조내상관계수(ICC)화변이계수(CV)진행비교.2개의기적일치성통과배대t검험화Bland-Ahman방법진행분석.결과 대우원추각막환자,UL-OCT측량치적중복성계수위3.43～4.31 μm,재현성계수위3.58～8.10 μm.중복성화재현성적조내상관계수분별위0.998화0.995이상.Pentacam측량치적중복성계수위8.63～14.30 μm,재현성계수위14.59～19.17 μm.중복성화재현성적조내상관계수분별위0.997화0.994이상.UL-OCT계통측량적각막후도재중앙구、방중앙구、과도구、주위구분별위(468.9 ±38.6) μm、(482.5 ±48.6) μm、(515.5 ±57.0)μm、(588.0±52.5)μm.Pentacam계통측량적각구각막후도분별위(500.9±50.0) μm、(533.9±49.7)μm、(587.9±60.6) μm、(635.3±62.0) μm.Bland-Ahman분석각막후도측량결과현시,2충의기측량결과차치적95％일치성계한재중앙구、방중앙구、과도구분별위-44.49～108.59 μm、-7.47～110.23 μm、-13.21～131.68 μm.결론 재측량원추각막환자전각막후도시,여Pentacam계통상비,UL-OCT계통구유경호적중복성화재현성.UL-OCT계통여Pentacam계통득도적각막후도측량결과존재차이,인차2충의기재림상응용시불가호환.
Objective To investigate the repeatability and reproducibility of mapping the entire corneal thickness of keratoconic patients using long scan depth spectral domain OCT (UL-OCT).Methods Ten patients (10 eyes) with keratoconus were recruited for this prospective study.A custom-buih UL-OCT system was used to obtain radial frames of corneal images.The 3D scan pattern consisted of equally located B-scans centered on the corneal vertex reflection.Corneal thickness maps were generated by a fully automated segmentation algorithm over a 10 mm diameter of the corneal region.Corneal thicknesses were measured in the central zone (0-2 mm),pericentral zone (＞2-5 mm),transitional zone (＞5-7 mm) and peripheral zone (＞7-10 mm).The results were compared with those obtained with a Pentacam.The intraobserver repeatability and interobsever reproducibility of the two systems were analyzed by a coefficient of repeatability (CoR),coefficient of reproducibility (CoR),intraclass correlation coefficient (ICC) and coefficient of variation (CV).The differences between the two systems were analyzed by a paired t test and Bland-Altman method.Results For keratoconus UL-OCT measurements,the coefficients of repeatability were less than 4.31 μm and the coefficients of reproducibility were less than 8.10 μm.The intraclass correlation coefficients of repeatability and reproducibility were more than 0.998 and 0.995.For the Pentacam topography of keratoconic patients,the coefficients of repeatability were less than 14.30 μm and coefficients of reproducibility was less than 19.17 μm.ICCs of repeatability and reproducibility were more than 0.997 and 0.994.The UL-OCT system measurements of corneal thickness in the central zone,pericentral zone,transitional zone and peripheral zone were 468.9±38.6 μm,482.5±48.6 μm,515.5±57.0 μm,and 588.0±52.5 μm,respectively.Pentacam system measurements of corneal thickness in the same zones were 500.9±50.0 μm,533.9±49.7 μm,587.9±60.6 μm,and 635.3±62.0 μm,respectively.The Bland-Altman analysis showed that the 95％ limits of agreement between the two instruments in the central zone,pericentral zone,transitional zone were-44.49 to 108.59 μm,-7.47 to 110.23 μm,and 13.21 to 131.68 μm,respectively.Conclusion There were significant differences in thickness measurements between UL-OCT and Pentacam topography,which makes these two devices non-interchangeable in the clinic.
