CAJ | 학술논문

肠紧密连接相关蛋白表达的改变影响着肠黏膜的屏障功能,是参与炎症性肠病发病的重要因素.有研究借助不同的技术检测出炎症性肠病中肠紧密连接蛋白的表达水平,但导致其改变的机制尚不完全清楚.探讨肠紧密连接蛋白改变的相关可能性机制有利于了解炎症性肠病的发病机制.改善肠紧密连接蛋白的表达成为治疗炎症性肠病的策略之一,其中一些药物已被证实有良好治疗效果.
장긴밀련접상관단백표체적개변영향착장점막적병장공능,시삼여염증성장병발병적중요인소.유연구차조불동적기술검측출염증성장병중장긴밀련접단백적표체수평,단도치기개변적궤제상불완전청초.탐토장긴밀련접단백개변적상관가능성궤제유리우료해염증성장병적발병궤제.개선장긴밀련접단백적표체성위치료염증성장병적책략지일,기중일사약물이피증실유량호치료효과.
The changes in tight junction proteins expression have effects on the function of the intestinal barrier.It is an important factor involved in the pathogenesis of inflammatory bowel disease.The levels of expression of tight junction proteins have been detected by different techniques in inflammatory bowel disease.The mechanism which leads to changes of tight junction proteins is still unknown completely.It is helpful to understand the pathogenesis of inflammatory of bowel disease by discussing the mechanism of changes in tight junction proteins.Improving expression of tight junction proteins is one of our strategies to treat inflammatory bowel disease,and some drugs have been identified.