CAJ | 학술논문

多发性骨髓瘤(MM)是发生于骨髓的多灶性浆细胞肿瘤,尽管造血干细胞移植及新型靶向药物的应用延长了患者总体的生存率,但是由于内在或获得性化疗的耐药性,MM仍然是不可治愈的疾病.骨髓中MM细胞和骨髓间质细胞(SC)间的相互依存关系导致了一些具有血管生成潜能的细胞因子(VEGF、IL-6等)的过度增生,它们通过旁分泌或自分泌的途径促进MM细胞的生存和增生.有学者认为,血管发生是肿瘤生长和转移的前提,而丰富的临床前和临床资料证明了血管发生在MM中的重要性.对MM中与血管生成相关的细胞因子及具有血管生成抑制功能的新型药物进行概括,以更清楚地了解MM的发病机制和治疗靶向.
다발성골수류(MM)시발생우골수적다조성장세포종류,진관조혈간세포이식급신형파향약물적응용연장료환자총체적생존솔,단시유우내재혹획득성화료적내약성,MM잉연시불가치유적질병.골수중MM세포화골수간질세포(SC)간적상호의존관계도치료일사구유혈관생성잠능적세포인자(VEGF、IL-6등)적과도증생,타문통과방분비혹자분비적도경촉진MM세포적생존화증생.유학자인위,혈관발생시종류생장화전이적전제,이봉부적림상전화림상자료증명료혈관발생재MM중적중요성.대MM중여혈관생성상관적세포인자급구유혈관생성억제공능적신형약물진행개괄,이경청초지료해MM적발병궤제화치료파향.
Multiple myeloma(MM)is a BM-based,multifocal plasma cell neoplasm.Despite of haemopoietic stem cells transplantation and the treatment of the novel targeted drugs,MM is still incurable because of internal or acquired drug resistance.The adherence of myeloma cells to BM stromal cells leads to the overproduction of several cytokines with angiogenic properties that enhance the survival and growth of myeloma cells through paracrine and autocrine loops.Some scientists think that angiogenesis is the precondition of turnouts growth and metastasis.Various preclinical'and clinical data have proved the importance of angiogenesis in MM.This review summarizes several cytokines related to angiogenesis(VEGF et a1.)and novel agents which have the property of angiogenesis inhibition,such as thalidomide and bortezomib,so that we can better understand the pathogenesis and therapy targets of MM.