CAJ | 학술논문

缺氧诱导因子-1(HIF-1)是在缺氧条件下广泛存在于人体内的一种转录因子.人类多数肿瘤内部有显著的缺氧区域,HIF-1在维持氧稳定、细胞能量代谢、肿瘤血管形成、细胞增生与凋亡等很多方面都起着重要作用.就HIF-1的生物学特性,HIF-1在多发性骨髓瘤发生、发展中的作用及其对预后的影响等研究进展进行了阐述.
결양유도인자-1(HIF-1)시재결양조건하엄범존재우인체내적일충전록인자.인류다수종류내부유현저적결양구역,HIF-1재유지양은정、세포능량대사、종류혈관형성、세포증생여조망등흔다방면도기착중요작용.취HIF-1적생물학특성,HIF-1재다발성골수류발생、발전중적작용급기대예후적영향등연구진전진행료천술.
Hypoxia-inducible factor 1(HIF-1)is a transcription factor in the human body when the environment is laek of oxygen.The latest studies showed that most of human tumor should be exposed to hypoxia.HIF-1 plays an important functions in keeping stabilization of oxygen,cell energy metabolism,the vasifaction of tumor,cell proliferation and apoptosis.The biological characteristics of HIF-1,and its roles in formation,development and prognostic affection in multiple myeloma were discussed in this article.