广东化工
廣東化工
엄동화공
GUANGDONG CHEMICAL INDUSTRY
2012年
5期
65-66
,共2页
均相法%Friedel-Crafts反应%对异丙基苯胺%合成条件优化
均相法%Friedel-Crafts反應%對異丙基苯胺%閤成條件優化
균상법%Friedel-Crafts반응%대이병기분알%합성조건우화
homogeneous method%Friedel-Crafts reaction%4-isopropylaniline%optimization of synthetic condition
以无水三氯化铝为催化剂,1,2-二氯乙烷为溶剂,通过Friedel-Crafts反应直接由氯代异丙烷和苯胺合成了对异丙基苯胺;用元素分析、FT-IR和1H NMR等方法表征了产物结构,正交实验方法优化了反应条件。结果表明,在反应温度为8℃、反应时间为60 min、无水三氯化铝对苯胺的摩尔比为1.3、氯代异丙烷对苯胺的摩尔比为1.5时,对异丙基苯胺对苯胺的收率可达70.9%。
以無水三氯化鋁為催化劑,1,2-二氯乙烷為溶劑,通過Friedel-Crafts反應直接由氯代異丙烷和苯胺閤成瞭對異丙基苯胺;用元素分析、FT-IR和1H NMR等方法錶徵瞭產物結構,正交實驗方法優化瞭反應條件。結果錶明,在反應溫度為8℃、反應時間為60 min、無水三氯化鋁對苯胺的摩爾比為1.3、氯代異丙烷對苯胺的摩爾比為1.5時,對異丙基苯胺對苯胺的收率可達70.9%。
이무수삼록화려위최화제,1,2-이록을완위용제,통과Friedel-Crafts반응직접유록대이병완화분알합성료대이병기분알;용원소분석、FT-IR화1H NMR등방법표정료산물결구,정교실험방법우화료반응조건。결과표명,재반응온도위8℃、반응시간위60 min、무수삼록화려대분알적마이비위1.3、록대이병완대분알적마이비위1.5시,대이병기분알대분알적수솔가체70.9%。
4-Isopropylaniline was synthesized directly through Friedel-Crafts reaction with aniline and isopropyl chloride as raw material,aluminum chloride anhydrous as catalyst and 1,2-dichloroethane as solvent.The product was characterized by elementary analysis,FT-IR and ＇HNMR,the synthetic condition was optimized using orthogonal experiment and the content of 4-Isopropylaniline in product was determined by GC.The experimental result indicated that the yield of 4-isopropylaniline could up to 70.9 % when the reaction temperature was 8.0 ℃,the reaction times were 60 minute,the molar ratio of aluminum chloride anhydrous to aniline was 1.3 and the molar ratio of isopropyl chloride to aniline was 1.5.
