CAJ | 학술논문

透明质酸（Hyaluronic Acid,HA）作为滑液和细胞外基质中一种丰富的糖氨聚糖成分,具有良好的生物相容性和可降解性。但天然透明质酸的力学性能较差,降解速度快,在生物体内不稳定。利用交联反应制成交联透明质酸衍生物可制成稳定性较强的生物材料,得以广泛应用。文章综述了近年来透明质酸分子与各种交联剂交联改性制成透明质酸衍生物的研究,为开发新型透明质酸衍生物生物材料提供参考和选择。
투명질산（Hyaluronic Acid,HA）작위활액화세포외기질중일충봉부적당안취당성분,구유량호적생물상용성화가강해성。단천연투명질산적역학성능교차,강해속도쾌,재생물체내불은정。이용교련반응제성교련투명질산연생물가제성은정성교강적생물재료,득이엄범응용。문장종술료근년래투명질산분자여각충교련제교련개성제성투명질산연생물적연구,위개발신형투명질산연생물생물재료제공삼고화선택。
Hyaluronic Acid（HA）,an abundant glycosaminoglycan component of synovial fluid and extracellular matrices with excellent biocompatibility.Owing to the unstability of native hyaluronic acid resulted from its water-solubility and fast degradation in vivo,it needs to be chemically modified to enhance its stability.This review concentrates on recent researches about the preparation of HA derivatives by cross-linking and biocompatibility,this is expected to provide valuable reference for preparation of new medicinal supports and biomaterials.