CAJ | 학술논문

5-氟尿嘧啶及其衍生物是临床上一类抗瘤谱广、效率高的抗代谢药物。寻求高效低毒、高选择性和高靶向性的5-氟尿嘧啶衍生物是目前抗肿瘤药物研究领域的一个热点。本文对5-氟尿嘧啶的各种结构修饰及其生物活性研究进行了总结，将为5-氟尿嘧啶衍生物的研究产生较大的促进作用。
5-불뇨밀정급기연생물시림상상일류항류보엄、효솔고적항대사약물。심구고효저독、고선택성화고파향성적5-불뇨밀정연생물시목전항종류약물연구영역적일개열점。본문대5-불뇨밀정적각충결구수식급기생물활성연구진행료총결，장위5-불뇨밀정연생물적연구산생교대적촉진작용。
5-Fluorouracil and its derivatives are a kind of effective antimetabolic drug used in clinic and have a broad antitamor spectrum. The search for highly effective, lowly toxic, highly selectivity and targeting activity 5- fluorouraeil derivatives has become a hot point in the field of antitumor drugs research now. In this paper, varied structure modification of 5-fluorouracil derivatives and their biological activity studies were reviewed, which will accelerate the further research of 5-fluorouracil derivatives.