CAJ | 학술논문

三聚氰胺（melamine,MA）对小鼠的经口LD50为4550mg/（kg.bw）,急性毒性属于低毒物质。为证实和客观评价其慢性毒性,以每千克饲料500、1000和2000mgMA/kg饲料的剂量对6周龄雌性Wistar大鼠进行了6个月慢性毒性试验。结果表明,各剂量组雌性Wistar大鼠肾、肝和膀胱均有不同程度地功能异常和器质性病变;血液ALT、AST、CRE和UA等生化指标均有不同程度地升高,肾、肝和膀胱黏膜均有不同程度地病理变化或损伤;每千克饲料2000mgMA/kg饲料的剂量能够抑制大鼠生长和采食,肾病理变化显著,出现结石;染毒组大鼠脾脏、骨髓等未见病变;MA对大鼠的最大无作用剂量应小于（35.7±15.4）mg/（kg.bw.d）。
삼취청알（melamine,MA）대소서적경구LD50위4550mg/（kg.bw）,급성독성속우저독물질。위증실화객관평개기만성독성,이매천극사료500、1000화2000mgMA/kg사료적제량대6주령자성Wistar대서진행료6개월만성독성시험。결과표명,각제량조자성Wistar대서신、간화방광균유불동정도지공능이상화기질성병변;혈액ALT、AST、CRE화UA등생화지표균유불동정도지승고,신、간화방광점막균유불동정도지병리변화혹손상;매천극사료2000mgMA/kg사료적제량능구억제대서생장화채식,신병리변화현저,출현결석;염독조대서비장、골수등미견병변;MA대대서적최대무작용제량응소우（35.7±15.4）mg/（kg.bw.d）。
Melamine（MA） is a low-acute toxicity chemical with LD50 of 4 550 mg/（kg·bw） in mice.To verify and evaluate its chronic toxicity,500,1 000 and 2 000 mg MA per kilogram feed were fed to 6-week-old female Wistar rats for six months.The results showed that functional disorders and organic changes of kidney,liver and ladder of female Wistar rats to different extent were observed in each test group.The blood biochemical indices（such as ALT,AST,CRE and UA） increased to different extent.The histological abnormalities or damages to different extent were found in kidney,liver and bladder.In 2 000 mg MA/kg dose group,the growth and feed intake were inhibited and histological change or damage of kidney was significant,even kidney calculi appeared.In poisoned group,no histological abnormality was found in spleen and bone marrow of rats.Maximal no-effect dose of MA on rats should be less than（35.7±15.4） mg/（kg·bw·d）.