辽宁师专学报：自然科学版
遼寧師專學報：自然科學版
료녕사전학보：자연과학판
Journal of Liaoning Teachers College(Natural Science Edition)
2012年
1期
1-4,95
,共5页
HIV-I%转录%NF-kB%Rev%Tat%抑制剂
HIV-I%轉錄%NF-kB%Rev%Tat%抑製劑
HIV-I%전록%NF-kB%Rev%Tat%억제제
HIV-I%transcription%NF-kB%Rev%Tat%inhibitors
人类免疫缺陷病毒（human immunodeficiency virus,HIV）和获得性免疫缺陷综合症（acquiredimmunodeficiency syndrome,AIDS）仍是全球关注的健康问题,研究开发抗HIV抑制剂具有重要的意义.细胞核因子kB（nuclear factor kappa B,NF-kB）、反式激活因子（trans-activator of transcription,Tat）、病毒颗粒蛋白表达调节因子（regulator of virion protein expression,Rev）是人免疫缺陷病毒I型（human immunodeficiency virustype I,HIV-I）转录过程中不可缺少的调控蛋白.综述NF-kB、Tat、Rev蛋白的结构、功能、作用机理及相关抑制剂的研究进展.
人類免疫缺陷病毒（human immunodeficiency virus,HIV）和穫得性免疫缺陷綜閤癥（acquiredimmunodeficiency syndrome,AIDS）仍是全毬關註的健康問題,研究開髮抗HIV抑製劑具有重要的意義.細胞覈因子kB（nuclear factor kappa B,NF-kB）、反式激活因子（trans-activator of transcription,Tat）、病毒顆粒蛋白錶達調節因子（regulator of virion protein expression,Rev）是人免疫缺陷病毒I型（human immunodeficiency virustype I,HIV-I）轉錄過程中不可缺少的調控蛋白.綜述NF-kB、Tat、Rev蛋白的結構、功能、作用機理及相關抑製劑的研究進展.
인류면역결함병독（human immunodeficiency virus,HIV）화획득성면역결함종합증（acquiredimmunodeficiency syndrome,AIDS）잉시전구관주적건강문제,연구개발항HIV억제제구유중요적의의.세포핵인자kB（nuclear factor kappa B,NF-kB）、반식격활인자（trans-activator of transcription,Tat）、병독과립단백표체조절인자（regulator of virion protein expression,Rev）시인면역결함병독I형（human immunodeficiency virustype I,HIV-I）전록과정중불가결소적조공단백.종술NF-kB、Tat、Rev단백적결구、공능、작용궤리급상관억제제적연구진전.
HIV and AIDS remain a health problem of global concern.Therefor e,research and development of anti-HIV-I inhibitors is of great significance. N F-kB,Tat and Rev are the indispensable regulatory protein in the process of tr a nscription.In this paper,the structure,function,mechanism and related inhibi tors of NF-kB,Tat and Rev are reviewed.
