CAJ | 학술논문

目的探讨bcl-2蛋白在原发胃肠道弥漫性大B细胞淋巴瘤(DLBCL)以及原发结内DLBCL中的预后提示作用.方法收集北京大学基础医学院病理学系血液病理研究室确诊为DLBCL,且非利妥昔单抗化疗的患者93例.用免疫组织化学检测bcl-2、CD_(10)、bcl-6、Mum-1表达情况.随访全部患者的治疗过程和预后.采用SAS 9.1统计学软件对所得资料行X2检验、生存曲线分析及Log-Rank检验.结果原发于胃肠道DLBCL 46例.bcl-2(+)病例26例,完全缓解(CR)8例;bcl-2(-)病例20例,CR 10例.两者CR率差异无统计学意义(X~2 检验,P=0.1852),两组的生存时间差异无统计学意义(Log-Rank检验,P=0.4663).原发于淋巴结DLBCL47例.bcl-2(+)病例30例.CR 8例;bcl-2(-)病例17例,CR 10例.两者CR率差异具有统计学意义(X~2检验,P=0.0293),两组的生存时间差异具有统计学意义(Log-Rank检验,P=0.0470).结论 bcl-2蛋白对原发淋巴结内DLBCL有预后提示意义,而在原发胃肠道DLBCL中无预后提示意义.
목적 탐토bcl-2단백재원발위장도미만성대B세포림파류(DLBCL)이급원발결내DLBCL중적예후제시작용.방법 수집북경대학기출의학원병이학계혈액병리연구실학진위DLBCL,차비리타석단항화료적환자93례.용면역조직화학검측bcl-2、CD_(10)、bcl-6、Mum-1표체정황.수방전부환자적치료과정화예후.채용SAS 9.1통계학연건대소득자료행X2검험、생존곡선분석급Log-Rank검험.결과 원발우위장도DLBCL 46례.bcl-2(+)병례26례,완전완해(CR)8례;bcl-2(-)병례20례,CR 10례.량자CR솔차이무통계학의의(X~2 검험,P=0.1852),량조적생존시간차이무통계학의의(Log-Rank검험,P=0.4663).원발우림파결DLBCL47례.bcl-2(+)병례30례.CR 8례;bcl-2(-)병례17례,CR 10례.량자CR솔차이구유통계학의의(X~2검험,P=0.0293),량조적생존시간차이구유통계학의의(Log-Rank검험,P=0.0470).결론 bcl-2단백대원발림파결내DLBCL유예후제시의의,이재원발위장도DLBCL중무예후제시의의.
Objective To explore the prognostic significance of bcl-2 protein in primary gastrointestinal DLBCL and primary nodal diffuse large B-cell lymphoma(DLBCL)by the clinical pathological analysis in 93 cases.Methods 93 cases of DLBCL without treatment of rituximab were collected from the haematopathological laboratory,the Department of Pathology of Beijing University Health Science Center.Immunohistochemical staining with Envision was used to assess the expression of bcl-2,CD_(10),bcl-6 and Mum1 and the treatment and prognosis of all cases followed up.The data were analyzed with Chi-square test,survival curve analysis and Log-Rank test by SAS 9.1.Results There were 46 patients of primary gastrointestinal DLBCL,in which 8 cases out of 26 patients with bcl-2(+)achieved CR and 10 cases out of 20 patients with bcl-2(-)achieved CR.There was no significant difference in CR(Chi-square test,P=0.1852)and OS(Log-Rank test,P=0.4663).Meanwhile,there were 47 patients of primary nodal DLBCL in this study,in which 8 cases out of 30 patients with bcl-2(+)achieved CR,10 cases out of 17 patients with bcl-2(-)achieved CR.There was a significant difference in CR(Chi-square test,P=0.0293)and OS(Log-Rank test,P=0.0470).Conclusion bcl-2 protein has a prognostic significance in primary nodal DLBCL but not in the primary gastrointestinal DLBCL.