CAJ | 학술논문

论文通过文献资料法、逻辑分析法等对骨髓间充质干细胞作用于心肌细胞凋亡应用,以及心肌细胞凋亡与Bcl-2和Bax蛋白表达的关系进行研究,旨在探讨骨髓间充质干细胞调控Bcl-2、Bax基因蛋白表达的方式对心肌细胞凋亡的作用机制。研究发现,心肌细胞凋亡与Bcl-2、Bax基因蛋白的表达存在高度相关性,通过调控Bcl-2、Bax的基因表达能够在一定程度上防止心肌细胞凋亡的发生与发展,而骨髓间充质干细胞则可以通过自身诱导分化的特性有效的调控Bcl-2和Bax蛋白的表达,使损伤后的心肌功能得到改善。
논문통과문헌자료법、라집분석법등대골수간충질간세포작용우심기세포조망응용,이급심기세포조망여Bcl-2화Bax단백표체적관계진행연구,지재탐토골수간충질간세포조공Bcl-2、Bax기인단백표체적방식대심기세포조망적작용궤제。연구발현,심기세포조망여Bcl-2、Bax기인단백적표체존재고도상관성,통과조공Bcl-2、Bax적기인표체능구재일정정도상방지심기세포조망적발생여발전,이골수간충질간세포칙가이통과자신유도분화적특성유효적조공Bcl-2화Bax단백적표체,사손상후적심기공능득도개선。
The paper through literature,logic analysis of bone marrow mesenchymal stem cells application in myocardial apoptosis and myocardial apoptosis and Bcl-2 and Bax protein expression studies to investigate the bone marrow mesenchymal stem cells Regulation of Bcl-2,Bax protein expression in the way of the mechanism of cardiomyocyte apoptosis.Through the study found that the incidence of myocardial apoptosis in the Bcl-2,Bax gene expression in high correlation exists,through regulation of Bcl-2,Bax gene expression to a certain extent,prevent the occurrence of myocardial apoptosis and development of The bone marrow mesenchymal stem cells can be induced to differentiate their properties through the effective regulation of Bcl-2 and Bax protein expression,the injury improved cardiac function.