CAJ | 학술논문

目的：探讨急性放射性肺损伤大鼠模型建立的研究。方法：SD大鼠40只随机分为10 Gy组、20 Gy组、30 Gy组以及对照组（不照射），每组10只。于直线加速器下行单次全胸5 Gy、10 Gy以及15 Gy照射，2次/周。于照射后第2周、第4周行CT扫描后随机处死5只，行右肺HE染色观察其病理变化。结果：4周内无大鼠死亡，于照射2周后总量20 Gy、30 Gy组均出现不同程度的皮毛倒翻、无光泽，呼吸急促，以及饮食、体重减少等情况，其中30 Gy组最为明显。病理切片、胸部CT显示20 Gy、30 Gy照射组于第2周、第4周均有不同程度的急性炎性反应，其中以30 Gy组最为显著。结论：30 Gy照射组为建立急性放射性肺损伤大鼠模型最佳照射剂量，为今后研究防治急性放射性肺损伤作用机制的筛选提供了基础。
목적：탐토급성방사성폐손상대서모형건립적연구。방법：SD대서40지수궤분위10 Gy조、20 Gy조、30 Gy조이급대조조（불조사），매조10지。우직선가속기하행단차전흉5 Gy、10 Gy이급15 Gy조사，2차/주。우조사후제2주、제4주행CT소묘후수궤처사5지，행우폐HE염색관찰기병리변화。결과：4주내무대서사망，우조사2주후총량20 Gy、30 Gy조균출현불동정도적피모도번、무광택，호흡급촉，이급음식、체중감소등정황，기중30 Gy조최위명현。병리절편、흉부CT현시20 Gy、30 Gy조사조우제2주、제4주균유불동정도적급성염성반응，기중이30 Gy조최위현저。결론：30 Gy조사조위건립급성방사성폐손상대서모형최가조사제량，위금후연구방치급성방사성폐손상작용궤제적사선제공료기출。
Objective Model of acute lung injury in rats radioactive established research.Methods SD rats were randomly divided into 40 groups 10 Gy,20 Gy group,30 Gy group and the control group(without irradiation),n=10.At the downstream single linear accelerator full chest 5 Gy,10 Gy and 15 Gy irradiation,2 times/week.In the first two weeks after irradiation,were sacrificed after 4 weeks 5 CT scan,the line of the right lung pathological changes observed by HE staining.Results No rats died within 4 weeks,2 weeks after irradiation in total 20 Gy,30 Gy group there are different degrees of fur spilled,dull,shortness of breath,as well as diet,weight loss,etc.,the most obvious of which 30 Gy group.Biopsy,chest CT showed 20 Gy,30 Gy irradiation group in the first two weeks,the first four weeks have varying degrees of acute inflammatory reaction,in which the most significant 30 Gy group.Conclusion 30 Gy irradiation group was established model of acute lung injury in rats optimal radiation dose for future studies of acute radiation-induced lung injury prevention screening mechanism provides a basis.