CAJ | 학술논문

近年来研究表明近视的发生发展与巩膜细胞外基质(ECM)的重塑关系密切,基质金属蛋白酶(MMPs)作为调控巩膜ECM动态平衡最重要的一大酶系,也受到越来越多的重视,其中对于MMP-2的研究最为广泛,作为探讨近视发病机制及治疗的靶因子,不仅有大量研究证明其活性增加与近视发展明显相关,很多通过抑制MMP-2来防治近视的研究也取得了丰硕的成果.现就MMP-2多年来在近视方面的研究进展做一综述.
근년래연구표명근시적발생발전여공막세포외기질(ECM)적중소관계밀절,기질금속단백매(MMPs)작위조공공막ECM동태평형최중요적일대매계,야수도월래월다적중시,기중대우MMP-2적연구최위엄범,작위탐토근시발병궤제급치료적파인자,불부유대량연구증명기활성증가여근시발전명현상관,흔다통과억제MMP-2래방치근시적연구야취득료봉석적성과.현취MMP-2다년래재근시방면적연구진전주일종술.
Recent studies indicate that the development of myopia is closely related to the remodeling of scleral extracellular matrix metalloproteinases,as the most important enzymes of regulating the scleral extracellular matrix have gained more and more attention,in which MMP-2 is the most widely studied.As a target factor in the study of the pathogenesis and treatment of myopia,not only a large number of studies have shown that its activity increased significantly associated with the development of myopia,many researches on myopia treatment also achieved fruitful results by inhibiting MMP-2.Years of researches of MMP-2 in myopia study is reviewed in this paper.