CAJ | 학술논문

肺间质纤维化是多种常见慢性肺部疾病发展的最终结局,由于该病的病死率极高,因此严重威胁人类健康和生命.目前肺间质纤维化具体发病机制尚未明确.尽管已形成的纤维化病理改变不能被逆转,但肺间质纤维化是一个进行性慢性的过程,因此探索肺间质纤维化发病的分子机制及干预靶点,对延缓或阻止肺间质纤维化进展具有重要意义.本文就TGF-β/Smad信号转导途径在肺间质纤维化中的机制研究及干预治疗进行综述.
폐간질섬유화시다충상견만성폐부질병발전적최종결국,유우해병적병사솔겁고,인차엄중위협인류건강화생명.목전폐간질섬유화구체발병궤제상미명학.진관이형성적섬유화병리개변불능피역전,단폐간질섬유화시일개진행성만성적과정,인차탐색폐간질섬유화발병적분자궤제급간예파점,대연완혹조지폐간질섬유화진전구유중요의의.본문취TGF-β/Smad신호전도도경재폐간질섬유화중적궤제연구급간예치료진행종술.
Pulmonary fibrosis is outcomes of lots of chronic lung disease.It is serious threat to human health for the high mortality rate.Now the pathogenesis of pulmonary fibrosis is not yet clear.To explore the mechanisms of pulmonary fibrosis and therapeutic intervention is of great significance.The article reviewed transforming growth factor-β/Smad signaling pathway and therapeutic intervention in pulmonary fibrosis.