国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2013年
12期
953-956
,共4页
肺癌%侵袭和转移%表皮生长因子受体%趋化因子受体4
肺癌%侵襲和轉移%錶皮生長因子受體%趨化因子受體4
폐암%침습화전이%표피생장인자수체%추화인자수체4
Lung cancer%Invasion and metastasis%Epidermal growth factor receptor%Chemokine receptor 4
目前,从分子水平了解肺癌发病机制、判断预后和明确生物靶点有助于提高其疗效.在多种恶性肿瘤中EGFR、CXCR4均有异常表达,并与肿瘤的侵袭、转移和预后密切相关.本研究通过对EGFR、CXCR4的检测和相关的研究,探讨二者在肺癌中的表达情况及对判断预后的意义,为肺癌的侵袭和转移的确诊及治疗提供新靶点.
目前,從分子水平瞭解肺癌髮病機製、判斷預後和明確生物靶點有助于提高其療效.在多種噁性腫瘤中EGFR、CXCR4均有異常錶達,併與腫瘤的侵襲、轉移和預後密切相關.本研究通過對EGFR、CXCR4的檢測和相關的研究,探討二者在肺癌中的錶達情況及對判斷預後的意義,為肺癌的侵襲和轉移的確診及治療提供新靶點.
목전,종분자수평료해폐암발병궤제、판단예후화명학생물파점유조우제고기료효.재다충악성종류중EGFR、CXCR4균유이상표체,병여종류적침습、전이화예후밀절상관.본연구통과대EGFR、CXCR4적검측화상관적연구,탐토이자재폐암중적표체정황급대판단예후적의의,위폐암적침습화전이적학진급치료제공신파점.
Currently,to understand the pathogenesis of lung cancer,to judge the prognosis,and to identify biological targets at the molecular level will be helpful to improve its efficacy.In a variety of malignant tumors,EGFR and CXCR4 show abnormal expression and they are closely related to invasion,metastasis,and prognosis of tumor.Through the detection of EGFR and CXCR4 expression and correlative study,this article investigates the expression of EGFR and CXCR4 in lung cancer and their significance for prognosis to provide new targets for final diagnosis and treatment of lung cancer.
