CAJ | 학술논문

　　目的探讨不同病期帕金森病患者睡眠障碍的发生率和相关因素。方法选取帕金森病患者60例，采用简明精神状态量表（MMSE）、Hoehn- Yahr分期(H- Y stage)、统一帕金森病评定量表（UPDRS）、汉密尔顿抑郁量表（HAMD）、匹兹堡睡眠质量指数量表（PSQI）分别评价患者认知功能、帕金森病疾病严重度、情绪状态以及睡眠质量。结果帕金森病患者睡眠障碍的发生率为78.3%，其中H- Y分期1~2期发生率为75.0%，2.5~3期发生率为65.0%，4期及以上发生率为95.0%，不同分期的患者睡眠障碍发生率的差异无统计学意义（P＞0.05）。女性睡眠障碍的发生率较男性高。多因素协方差分析显示睡眠障碍与性别、H- Y分期、HAMD分值呈正相关。睡眠障碍组与无睡眠障碍组患者在主观睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠干扰、催眠药物这6个因子的差异均有统计学意义（均P＜0.05）。结论睡眠障碍是帕金森病患者重要的非运动症状，在疾病的不同阶段均可发生，严重影响患者的生活质量。
　　목적탐토불동병기파금삼병환자수면장애적발생솔화상관인소。방법선취파금삼병환자60례，채용간명정신상태량표（MMSE）、Hoehn- Yahr분기(H- Y stage)、통일파금삼병평정량표（UPDRS）、한밀이돈억욱량표（HAMD）、필자보수면질량지수량표（PSQI）분별평개환자인지공능、파금삼병질병엄중도、정서상태이급수면질량。결과파금삼병환자수면장애적발생솔위78.3%，기중H- Y분기1~2기발생솔위75.0%，2.5~3기발생솔위65.0%，4기급이상발생솔위95.0%，불동분기적환자수면장애발생솔적차이무통계학의의（P＞0.05）。녀성수면장애적발생솔교남성고。다인소협방차분석현시수면장애여성별、H- Y분기、HAMD분치정정상관。수면장애조여무수면장애조환자재주관수면질량、입수시간、수면시간、수면효솔、수면간우、최면약물저6개인자적차이균유통계학의의（균P＜0.05）。결론수면장애시파금삼병환자중요적비운동증상，재질병적불동계단균가발생，엄중영향환자적생활질량。
Objective To observe the sleep quality in patients with Parkinson's disease and to investigate the prevalence and correlative factors of sleep disorders in patients with Parkinson's disease. Methods 60 patients with Parkinson's disease was enrol ed in our hospital. Mini- Mental State examination (MMSE),Hoehn- Yahr stage (H- Y stage),Unified Parkinson's Disease Rating Scale(UPDRS), Hamilton Depression Scale (HAMD), Pittsburgh Sleep Quality Index(PSQI) were used to evaluate the cog-nitive function, disease severity, emotion state and sleep quality. Results The prevalence of sleep disorders was 78.3%. The prevalences of sleep disorders among H- Y stage 1~2, 2.5~3 and≥4 were 75%,65%and 95%respectively. There was no sig-nificant difference among three groups. The prevalence of sleep disorders was higher in female than in male which was statisti-cal y different. Multiple coefficient chi- square test showed that sex, H- Y stage, scores of HAMD were correlated with sleep dis-orders. There were different on subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep distur-bance, hyphotic drugs between sleep disorder group and non sleep disorder groups. Conclusion Sleep disorders were impor-tant non motor symptoms of Parkinson's disease, which can occour in any stage of the disease and significantly influence pa-tients' quality of life.