中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
z1期
42-43
,共2页
CA199糖尿病%2型%胰腺癌
CA199糖尿病%2型%胰腺癌
CA199당뇨병%2형%이선암
CA199%Type-2 diabetes mellitus%Pancreatic cancer
目的 比较2型糖尿病患者与年龄与性别匹配正常人的血清癌抗原(CA)199水平.方法 选择60例2型糖尿病患者(糖尿病组)和40例健康体检者(对照组),检测并比较两组血清CA199、空腹血糖、餐后血糖及糖化血红蛋白水平.结果 糖尿病组血清CA199水平为(45.2±18.6) U/ml,高于对照组的(11.3±6.4) U/ml,差异有统计学意义(P＜0.01),Pearson相关分析显示血清CA199水平与空腹血糖、餐后血糖及糖化血红蛋白水平无相关性.结论 CA199是诊断胰腺癌的指标,但也可以作为糖尿病引起的胰腺组织损伤的一个标志.检测2型糖尿病患者CA199水平应该高于其正常参考值范围去评价,以利于正确评估良恶性胰腺疾病.2型糖尿病患者轻度升高的CA199或许反映了患者胰腺外分泌功能紊乱.
目的 比較2型糖尿病患者與年齡與性彆匹配正常人的血清癌抗原(CA)199水平.方法 選擇60例2型糖尿病患者(糖尿病組)和40例健康體檢者(對照組),檢測併比較兩組血清CA199、空腹血糖、餐後血糖及糖化血紅蛋白水平.結果 糖尿病組血清CA199水平為(45.2±18.6) U/ml,高于對照組的(11.3±6.4) U/ml,差異有統計學意義(P＜0.01),Pearson相關分析顯示血清CA199水平與空腹血糖、餐後血糖及糖化血紅蛋白水平無相關性.結論 CA199是診斷胰腺癌的指標,但也可以作為糖尿病引起的胰腺組織損傷的一箇標誌.檢測2型糖尿病患者CA199水平應該高于其正常參攷值範圍去評價,以利于正確評估良噁性胰腺疾病.2型糖尿病患者輕度升高的CA199或許反映瞭患者胰腺外分泌功能紊亂.
목적 비교2형당뇨병환자여년령여성별필배정상인적혈청암항원(CA)199수평.방법 선택60례2형당뇨병환자(당뇨병조)화40례건강체검자(대조조),검측병비교량조혈청CA199、공복혈당、찬후혈당급당화혈홍단백수평.결과 당뇨병조혈청CA199수평위(45.2±18.6) U/ml,고우대조조적(11.3±6.4) U/ml,차이유통계학의의(P＜0.01),Pearson상관분석현시혈청CA199수평여공복혈당、찬후혈당급당화혈홍단백수평무상관성.결론 CA199시진단이선암적지표,단야가이작위당뇨병인기적이선조직손상적일개표지.검측2형당뇨병환자CA199수평응해고우기정상삼고치범위거평개,이리우정학평고량악성이선질병.2형당뇨병환자경도승고적CA199혹허반영료환자이선외분비공능문란.
Objective To investigate serum CA 199 levels in type 2 diabetic patients in comparison with age-and gender-matched control subjects.Methods We recorded FPG,2hPG,HbA1c levels and serum CA 199 levels in 60 type 2 diabetic patients and 40 controls.Abdominal CT was performed in order to eliminate abdominal malignancy in the diabetic groups.Results The average CA 199 level was 45.2 ±18.6U/mL for diabetic patients whereas it was 11.3 ± 6.4 U/mL for the control group (P ＜ 0.01).Serum CA 199 had no correlation with FPG,2hPG and HbA1c levels.For all patients,abdominal CT showed no pancreatic abnormalities.Conclusion CA199 is used in the diagnosis of pancreatic cancer but is also a marker of pancreatic tissue damage that might be caused by diabetes.We propose that a higher cut-off value of CA 199should be used in diabetics to differentiate benign and malignant pancreatic disease,and subtle elevations of CA 199 in diabetics should be considered as the indication of exocrine pancreatic dysfunction.
