中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2009年
5期
441-444
,共4页
王丁丁%柳夏林%于强%卢彦
王丁丁%柳夏林%于彊%盧彥
왕정정%류하림%우강%로언
糖尿病视网膜病变%神经生长因子(NGF)%脑源性神经营养因子(BDNF)%新生血管%糖化血红蛋白(HbA1c)
糖尿病視網膜病變%神經生長因子(NGF)%腦源性神經營養因子(BDNF)%新生血管%糖化血紅蛋白(HbA1c)
당뇨병시망막병변%신경생장인자(NGF)%뇌원성신경영양인자(BDNF)%신생혈관%당화혈홍단백(HbA1c)
Diabetic retinopathy%Neurotrophic growth factor%Brain-derived neurotrophic factor%An-giogenesis%HbA1c
目的 探讨NGF、BDNF是否参与和促进糖尿病视网膜病变新生血管的形成.方法 将研究对象分四组:正常健康(CG)组20例,糖尿病无视网膜病组(NDR)50例,非增生性糖尿病视网膜病变(NPDR)组50例,增生性糖尿病变视网膜病变(PDR)50例.收集临床资料:年龄、糖尿病类型、糖尿病病程、收缩压(SBP)、舒张压(DBP)、糖化血红蛋白(HbA1c)、尿素氮(BUN)、肌酐(Cr),采用酶联免疫吸附测定法(ELISA)检测外周血血浆NGF、BDNF含量.结果 PDR患者血浆中NGF、BDNF水平(5.014±0.536ng/ml,(2.679±0.637)ng/ml高于CG组(3.549±0.426)ng/ml,(1.135±0.394)ng/ml、NDR组(3.556±0.962)ng/ml,(1.375±0.944)ng/ml、NPDR组(3.732±1.363)ng/ml,(1.504±1.191)ng/ml,比较差异有统计学意义.血浆NGF、BDNF水平与糖尿病病程、HbA1c有正相关性(NGF:r=0.821,0.828;BDNF:r=0.876,0.902,P<0.01).结论 糖尿病视网膜病变患者的外周血NGF、BDNF水平升高,并与糖尿病病程、HbA1c的水平成正相关.糖尿病视网膜病变患者的外周血NGF、BDNF水平的升高,可能参与促进了视网膜新生血管的形成.
目的 探討NGF、BDNF是否參與和促進糖尿病視網膜病變新生血管的形成.方法 將研究對象分四組:正常健康(CG)組20例,糖尿病無視網膜病組(NDR)50例,非增生性糖尿病視網膜病變(NPDR)組50例,增生性糖尿病變視網膜病變(PDR)50例.收集臨床資料:年齡、糖尿病類型、糖尿病病程、收縮壓(SBP)、舒張壓(DBP)、糖化血紅蛋白(HbA1c)、尿素氮(BUN)、肌酐(Cr),採用酶聯免疫吸附測定法(ELISA)檢測外週血血漿NGF、BDNF含量.結果 PDR患者血漿中NGF、BDNF水平(5.014±0.536ng/ml,(2.679±0.637)ng/ml高于CG組(3.549±0.426)ng/ml,(1.135±0.394)ng/ml、NDR組(3.556±0.962)ng/ml,(1.375±0.944)ng/ml、NPDR組(3.732±1.363)ng/ml,(1.504±1.191)ng/ml,比較差異有統計學意義.血漿NGF、BDNF水平與糖尿病病程、HbA1c有正相關性(NGF:r=0.821,0.828;BDNF:r=0.876,0.902,P<0.01).結論 糖尿病視網膜病變患者的外週血NGF、BDNF水平升高,併與糖尿病病程、HbA1c的水平成正相關.糖尿病視網膜病變患者的外週血NGF、BDNF水平的升高,可能參與促進瞭視網膜新生血管的形成.
목적 탐토NGF、BDNF시부삼여화촉진당뇨병시망막병변신생혈관적형성.방법 장연구대상분사조:정상건강(CG)조20례,당뇨병무시망막병조(NDR)50례,비증생성당뇨병시망막병변(NPDR)조50례,증생성당뇨병변시망막병변(PDR)50례.수집림상자료:년령、당뇨병류형、당뇨병병정、수축압(SBP)、서장압(DBP)、당화혈홍단백(HbA1c)、뇨소담(BUN)、기항(Cr),채용매련면역흡부측정법(ELISA)검측외주혈혈장NGF、BDNF함량.결과 PDR환자혈장중NGF、BDNF수평(5.014±0.536ng/ml,(2.679±0.637)ng/ml고우CG조(3.549±0.426)ng/ml,(1.135±0.394)ng/ml、NDR조(3.556±0.962)ng/ml,(1.375±0.944)ng/ml、NPDR조(3.732±1.363)ng/ml,(1.504±1.191)ng/ml,비교차이유통계학의의.혈장NGF、BDNF수평여당뇨병병정、HbA1c유정상관성(NGF:r=0.821,0.828;BDNF:r=0.876,0.902,P<0.01).결론 당뇨병시망막병변환자적외주혈NGF、BDNF수평승고,병여당뇨병병정、HbA1c적수평성정상관.당뇨병시망막병변환자적외주혈NGF、BDNF수평적승고,가능삼여촉진료시망막신생혈관적형성.
Objective To measure serum nerve growth faetor(NGF)and brain-derived neurotrophic factor(BDNF)eoneentrations in diabetic patients to determine whether NGF and BDNF correlated with angiogenesis in proliferative diabetic retinopathy(PDR).Methods All participators were divided into four groups,20 nondiabetie controls and 50 non-diabetic retinopathy(NDR)patients and 50 non-proliferative diabetic retinopathy(NPDR)patients and 50 PDR patients.Patient demographic characteristics and diabetic parameters, including age, diabetes duration, HbA1c, renal function, were evaluated in two sepa-rate university hospitals.Serum NGF and BDNF concentrations were determined by using the ELISA teehnique. Results Serum NGF and BDNF levels were found to be higher in PDR patients(5.014±0.536)ng/ml, 2.679±0.637)ng/ml than in nondiabetic controls(3.549±0.426)ng/ml,(1.135±0.394)ng/ml and NDR pa-tients(3.556±0.962)ng/ml,(1.375±0.944)ng/ml and NPDR patients(3.732±1.363)ng/ml,(1.504±1.191) ng/ml. NGF and BDNF levels correlated well with diabetes duration,HbA1c(NGF:r=0.821,0.828;BDNF: r=0.876,0.902,P <0.01).Conclusions Elevated NGF and BDNF levels in PDR patients correlate well with diabetes duration, HbA1c.NGF and BDNF correlate with angiogenesis in PDR.
