中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2013年
14期
170-171,182
,共3页
腹腔镜%子宫肌瘤剔除术%垂体后叶素%缩宫素
腹腔鏡%子宮肌瘤剔除術%垂體後葉素%縮宮素
복강경%자궁기류척제술%수체후협소%축궁소
Laparoscopy%Hysteromyomectomy%Pituitrin%Oxytocin
目的观察大型内突壁间子宫肌瘤腹腔镜剔除术应用垂体后叶素及缩宫素止血的疗效对比。方法2010年1月～2012年6月对110例大型内突壁间子宫肌瘤施行腹腔镜子宫肌瘤剔除术；其中垂体后叶素组58例，切开浆膜层前子宫肌层注射垂体后叶素6 IU+0.9％氯化钠注射液10 mL；缩宫索组52例，注射缩宫素20 IU+0.9％氯化钠注射液10 mL。对两组手术时间、术中出血量、术后血红蛋白及用药前后血压的变化进行比较。结果两组手术均顺利完成，无中转开腹病例。垂体后叶素组手术时间（68.9±10.8）min与缩宫素组（88.2±17.6）min相比，明显减少（t=-3.538，P=0.021），术中出血量（65.8±16.9）mL vs（88.4±26.5）mL也明显减少（t=-3.153，P=0.033），术后血红蛋白下降幅度小[（10.1±2.9）g/L vs（15.2±2.2）g/L，t=-4.223，P=0.012]。术中用药后15 min，垂体后叶素组收缩压上升（156.2±5.8）mm Hg，显著高于缩宫素组[（135.6±12.0）mm Hg，t=3.289，P=0.039]，用药30 min和45 min后，垂体后叶素组与缩宫素组收缩压无显著性差异（P＞0.05）。结论大型内突壁间子宫肌瘤腹腔镜剔除术中使用垂体后叶素止血效果优于缩宫素，可明显减少术中出血，减少手术时间，值得推广应用。
目的觀察大型內突壁間子宮肌瘤腹腔鏡剔除術應用垂體後葉素及縮宮素止血的療效對比。方法2010年1月～2012年6月對110例大型內突壁間子宮肌瘤施行腹腔鏡子宮肌瘤剔除術；其中垂體後葉素組58例，切開漿膜層前子宮肌層註射垂體後葉素6 IU+0.9％氯化鈉註射液10 mL；縮宮索組52例，註射縮宮素20 IU+0.9％氯化鈉註射液10 mL。對兩組手術時間、術中齣血量、術後血紅蛋白及用藥前後血壓的變化進行比較。結果兩組手術均順利完成，無中轉開腹病例。垂體後葉素組手術時間（68.9±10.8）min與縮宮素組（88.2±17.6）min相比，明顯減少（t=-3.538，P=0.021），術中齣血量（65.8±16.9）mL vs（88.4±26.5）mL也明顯減少（t=-3.153，P=0.033），術後血紅蛋白下降幅度小[（10.1±2.9）g/L vs（15.2±2.2）g/L，t=-4.223，P=0.012]。術中用藥後15 min，垂體後葉素組收縮壓上升（156.2±5.8）mm Hg，顯著高于縮宮素組[（135.6±12.0）mm Hg，t=3.289，P=0.039]，用藥30 min和45 min後，垂體後葉素組與縮宮素組收縮壓無顯著性差異（P＞0.05）。結論大型內突壁間子宮肌瘤腹腔鏡剔除術中使用垂體後葉素止血效果優于縮宮素，可明顯減少術中齣血，減少手術時間，值得推廣應用。
목적관찰대형내돌벽간자궁기류복강경척제술응용수체후협소급축궁소지혈적료효대비。방법2010년1월～2012년6월대110례대형내돌벽간자궁기류시행복강경자궁기류척제술；기중수체후협소조58례，절개장막층전자궁기층주사수체후협소6 IU+0.9％록화납주사액10 mL；축궁색조52례，주사축궁소20 IU+0.9％록화납주사액10 mL。대량조수술시간、술중출혈량、술후혈홍단백급용약전후혈압적변화진행비교。결과량조수술균순리완성，무중전개복병례。수체후협소조수술시간（68.9±10.8）min여축궁소조（88.2±17.6）min상비，명현감소（t=-3.538，P=0.021），술중출혈량（65.8±16.9）mL vs（88.4±26.5）mL야명현감소（t=-3.153，P=0.033），술후혈홍단백하강폭도소[（10.1±2.9）g/L vs（15.2±2.2）g/L，t=-4.223，P=0.012]。술중용약후15 min，수체후협소조수축압상승（156.2±5.8）mm Hg，현저고우축궁소조[（135.6±12.0）mm Hg，t=3.289，P=0.039]，용약30 min화45 min후，수체후협소조여축궁소조수축압무현저성차이（P＞0.05）。결론대형내돌벽간자궁기류복강경척제술중사용수체후협소지혈효과우우축궁소，가명현감소술중출혈，감소수술시간，치득추엄응용。
Objective To compare the hemostasis effect of pituitrin and oxytocin in laparoscopic surgery for intramural hysteromyoma. Methods Clinical data of 110 cases with intramural hysteromyoma who underwent laparoscopic resection from January 2010 to June 2012,were enrolled into this study(58 cases in pituitrin group, 52 cases in oxytocin group).Before open placenta incision,the eases in pituitrin group were injected with pituitrin 6 IU+nornlal saline 10 mL and oxytoein group recieved 20 IU oxytocin+normal saline 10 mL.The blood pressure,operation time,blood loss during the operation and the postoperative change of hemoglobin were analyzed. Results All the operations were successfully completed without converting to transabdominal operation.The operation time of the pituitrin group were significantly shorter than that in the oxytocin group[(68.9±10.8)min vs (88.2±17.6)min,t=-3.538,P=0.021].The blood loss of the pituitrin group were significantly less than that of oxytocin group[(65.8±16.9) ml vs.(88.4±26.5)mL,t=-3.153,P=0.033].The decrease of hemoglobin after operation in pituitrin roup were smaller than that of oxytoein group[(10.1±2.9)g/L vs (15.2±2.2)g/L,t=-4.223,P=0.012].The blood pressureincreased 15 min after pituitrin injection in the pituitrin group to(156.2±5.8)mm Hg,which was significantly higher than that of oxytocin group[(135.6±12.0)mm Hg,t=3.289,P=0.039].No significant differences in blood pressure increase in 30 and 45 min after injection were observed between the two groups(P>0.05). Conclusion The effect of hemostasis with pituitrin in laparoscopy for intramural hysteromyoma is better than oxytoein.Injection of pituitrin can decrease intraoperative blood loss and shorten operation time.
