CAJ | 학술논문

　　目的探讨西比灵联合川芎嗪治疗椎-基底动脉供血不足性眩晕的临床疗效，为科学用药提供依据。方法回顾性分析在我院接受治疗的136例病椎-基底动脉供血不足性眩晕患者的临床资料，并在尊重其个人意愿的基础上将其分为西比灵组68例和联合治疗组68例。西比灵进行为期14 d，1天1次，1次10 mg的口服西比灵胶囊进行治疗；联合治疗组在西比灵治疗的基础上进行为期14 d，1次/d，1次200 mg的川芎嗪注射液的静脉滴注治疗。对两种治疗方法的临床疗效和安全性进行比较。结果联合治疗组的临床总有效率明显高于西比灵组，其临床总有效率可高达91.17%，差异具有统计学意义（P＜0.05）。联合治疗组的安全性（高达97.06%）优于西比灵组，差异有统计学意义（P＜0.05）。结论在治疗椎-基底动脉供血不足性眩晕的临床应用上，西比灵联合川芎嗪的疗效显著，是一种值得在临床上大力推广的联合治疗方案。
　　목적탐토서비령연합천궁진치료추-기저동맥공혈불족성현훈적림상료효，위과학용약제공의거。방법회고성분석재아원접수치료적136례병추-기저동맥공혈불족성현훈환자적림상자료，병재존중기개인의원적기출상장기분위서비령조68례화연합치료조68례。서비령진행위기14 d，1천1차，1차10 mg적구복서비령효낭진행치료；연합치료조재서비령치료적기출상진행위기14 d，1차/d，1차200 mg적천궁진주사액적정맥적주치료。대량충치료방법적림상료효화안전성진행비교。결과연합치료조적림상총유효솔명현고우서비령조，기림상총유효솔가고체91.17%，차이구유통계학의의（P＜0.05）。연합치료조적안전성（고체97.06%）우우서비령조，차이유통계학의의（P＜0.05）。결론재치료추-기저동맥공혈불족성현훈적림상응용상，서비령연합천궁진적료효현저，시일충치득재림상상대력추엄적연합치료방안。
Objective To discuss the clinical effect of sibelium combined with ligustrazine on vertebral-basilar ischemic vertigo(VBIV), and to provide scientific direction for drug application. Methods 136 cases of VBIV patients who were admitted into our hospital were retrospectively analyzed and were divided into sibelium group(68 cases) and combined treating group(68 cases) on the basis of respecting personal willingness.The sibelium group was treated with sibelium capsule 10mg at a time/d,the treatment course was 14 d,while the combined treating group was treated with ligustrazine injection 200mg at a time/d by intravenous drip.The clinical effect and safety of two methods were comparatively analyzed. Results The total clinical effect of combined treating group reached to 91.17%,and was obviously higher than sibelium group(P < 0.05).Meanwhile,the safety value of combined treating group reached to 97.06%,and was superior to sibelium group (P < 0.05).Conclusion As a combined treating method,sibelium combined with ligustrazine has a good effect on VBIV clinical therapy,it worth to be vigorously promoted in clinical treatment.