CAJ | 학술논문

　　目的探讨不同剂量的丙种球蛋白治疗重症手足口病患儿的疗效。方法选取2009年3月～2013年3月来院就诊的重症手足口病患儿97例，分为3组。在基础治疗的基础上，A组给予IVIG 0.2 g/（kg·d）治疗；B组予IVIG 1g/（kg·d）治疗。C组予羚羊角粉治疗。结果 A、B两组患者NSS好转、发热缓解、临床治愈时间比较，差异均无统计学意义（P＞0.05）。A、B两组与C组比较，NSS好转、发热缓解、临床治愈时间比较，差异均有统计学意义（P＜0.05）。A、B两组治疗10 d后复查脑脊液及心电图正常和异常率比较，差异均无统计学意义（P＞0.05）。结论及早使用IVIG对手足口病患儿疗效显著；使用大、小剂量IVIG治疗重症手足口病疗效相近。
　　목적탐토불동제량적병충구단백치료중증수족구병환인적료효。방법선취2009년3월～2013년3월래원취진적중증수족구병환인97례，분위3조。재기출치료적기출상，A조급여IVIG 0.2 g/（kg·d）치료；B조여IVIG 1g/（kg·d）치료。C조여령양각분치료。결과 A、B량조환자NSS호전、발열완해、림상치유시간비교，차이균무통계학의의（P＞0.05）。A、B량조여C조비교，NSS호전、발열완해、림상치유시간비교，차이균유통계학의의（P＜0.05）。A、B량조치료10 d후복사뇌척액급심전도정상화이상솔비교，차이균무통계학의의（P＞0.05）。결론급조사용IVIG대수족구병환인료효현저；사용대、소제량IVIG치료중증수족구병료효상근。
Objective To study the curative effect of children with different dose of gamma globulin in the treatment of severe hand-foot-mouth disease. Methods 97 cases in the hospital with severe hand foot and mouth disease in,from 2009 March to 2013 March were divided into 3 groups.On the basis of conventional treatment, A group was given IVIG 0.2g/(kg .d) treatment;group B was treated with IVIG 1g/(kg .d) treatment.C group was treated with antelope horn powder. Results NSS improving, fever,alleviate clinical cure time comparison between A and Bgroup,the difference was not statistically significant(P>0.05).But NSS improved,fever,alleviate clinical cure time comparison among A,B two group and C group,the differences were statistically significant(P < 0.05).A, B two groups after 10 d treatment cerebrospinal fluid and normal ECG and abnormal rate, the difference is not statistically significant(P > 0.05). Conclusion Early use of IVIG significantly in children with hand-foot-and-mouth disease curative has effect;The use of large, small doses of IVIG had similar effect in treatment of severe hand-foot-mouth disease.