CAJ | 학술논문

　　目的观察常规疗法加乙酰半胱氨酸口服对慢性阻塞性肺疾病（COPD）患者肺通气功能及血清细胞因子IL-8、TNF-a、IL-10改变的影响。方法将COPD急性加重期的85例患者随机分为A、B两组。A组（治疗组）45例，在常规治疗基础上加用乙酰半胱氨酸胶囊400 mg口服，每日3次，连用10 d。B组（对照组）40例，仅常规治疗，不加用乙酰半胱氨酸胶囊口服。治疗前后观察肺通气功能、血气分析及血清细胞因子（IL-8、TNF-a、IL-10）的改变。结果 A、B两组患者经治疗后肺通气功能及动脉血气分析指标均有好转，血清IL-8、TNF-a、IL-10的表达亦均有改善，并且A组优于B组（P＜0.05）。结论乙酰半胱氨酸可有效改善COPD患者呼吸功能，改善血清IL-8、TNF-a、IL-10的表达。
　　목적관찰상규요법가을선반광안산구복대만성조새성폐질병（COPD）환자폐통기공능급혈청세포인자IL-8、TNF-a、IL-10개변적영향。방법장COPD급성가중기적85례환자수궤분위A、B량조。A조（치료조）45례，재상규치료기출상가용을선반광안산효낭400 mg구복，매일3차，련용10 d。B조（대조조）40례，부상규치료，불가용을선반광안산효낭구복。치료전후관찰폐통기공능、혈기분석급혈청세포인자（IL-8、TNF-a、IL-10）적개변。결과 A、B량조환자경치료후폐통기공능급동맥혈기분석지표균유호전，혈청IL-8、TNF-a、IL-10적표체역균유개선，병차A조우우B조（P＜0.05）。결론을선반광안산가유효개선COPD환자호흡공능，개선혈청IL-8、TNF-a、IL-10적표체。
Objective To observe changes and effects of conventional treatment plus oral Acetylcysteine on COPD patients' pulmonary ventilation function and serum cytokines IL-8, TNF-a, and IL-10. Methods Eighty-five patients with acute exacerbation of COPD were randomly divided into Group A and Group B. Forty-five patients in group A which were treated with acetylcysteine, besides conventional treatments, also were taken acetylcysteine pills (400 mg) tid for 10 days. At the same time, forty patients in group B for comparison only were received conventional treatment without any acetylcysteine pills. The changes of lung function, blood gas analysis and serum cytokines IL-8, TNF-a, and IL-10 before and after the treatment were observed. Results Pulmonary ventilation function, arterial blood gas and serum cytokines IL-8, TNF-a and IL-10 were improved in all patients from both groups A and B. And group A is even better than group B (P<0.05). Conclusion Acetylcysteine can effectively improve COPD patients' respiratory function and indicators of serum IL-8, TNF-a and IL10.