CAJ | 학술논문

　　目的探讨Pre-S1、S2抗原检测在乙型肝炎临床诊断中的作用及价值。方法回顾性分析2010年6月~2012年6月笔者所在医院就诊的Pre-S1、Pre-S2抗原检测为阳性和两项检测结果均为阳性的患者各50例临床资料，根据检查方法分为Pre-S1组、Pre-S2组与观察组。所有患者均进行HBV-DNA含量检测，＞1.0×103 copiese/mL即为阳性，比较三组患者HBV-DNA检出率。结果观察组HBV-DNA检出率为94.0%，明显高于Pre-S1组（86.0%）与Pre-S2组（80.0%），差异具有统计学意义（P＜0.05）。结论临床上检测Pre-S1、S2抗原的含量可以为乙肝病毒的复制提供可靠地依据，如果在同一个样本中检测出Pre-S1、S2两种抗原，则可以说明乙肝病毒已经复制。
　　목적탐토Pre-S1、S2항원검측재을형간염림상진단중적작용급개치。방법회고성분석2010년6월~2012년6월필자소재의원취진적Pre-S1、Pre-S2항원검측위양성화량항검측결과균위양성적환자각50례림상자료，근거검사방법분위Pre-S1조、Pre-S2조여관찰조。소유환자균진행HBV-DNA함량검측，＞1.0×103 copiese/mL즉위양성，비교삼조환자HBV-DNA검출솔。결과관찰조HBV-DNA검출솔위94.0%，명현고우Pre-S1조（86.0%）여Pre-S2조（80.0%），차이구유통계학의의（P＜0.05）。결론림상상검측Pre-S1、S2항원적함량가이위을간병독적복제제공가고지의거，여과재동일개양본중검측출Pre-S1、S2량충항원，칙가이설명을간병독이경복제。
Objective To study the Clinical diagnosis value and function of combined detection of Pre-S1 and Pre-S2 antigen in patients with hepatitis B. Methods The clinical data of Pre-S1 positive 50 patients, Pre-S2 positive 50 patients and two antigens positive 50 patients in our hospital from June 2010 to June 2012 were chosen and retrospectively analyzed. All patients were divided into the Pre-S1 group (50 cases), Pre-S2 group(50 cases) and experiment group (50 cases) according to the detection method. All the patients were given HBV-DNA content detection,of which more than 1×103 copiese/mL was positive.The HBV-DNA detection rates of three groups were compared. Results The HBV-DNA detection rate of experiment group was 94%, significantly higher than that of Pre-S1 group 86.0% and Pre-S2 group 80.0%.The differences were statistically significant(P<0.05). Conclusion Determination of Pre-S1, S2 antigen can provide reliable basis for HBV-DNA replication in the clinical,If Pre-S1 and S2 antigen is detected in the same sample,that can explain the hepatitis B virus has been copied.