CAJ | 학술논문

　　目的探讨氨磷汀对免疫性血小板减少性紫癜（ITP）动物模型小鼠血小板、脾脏系数、骨髓巨噬细胞的影响。方法通过获取BALB/C 小鼠血小板抗体，接种到豚鼠身上，获取豚鼠抗小鼠血小板抗体（APS）。将APS腹腔注射BALB/C 小鼠建立免疫性血小板减少性紫癜动物模型，使用氨磷汀腹腔注射进行治疗，观察氨磷汀对模型小鼠的血小板、脾脏系数、骨髓巨噬细胞的影响。结果氨磷汀给药后均使ITP模型小鼠血小板计数上升、脾脏系数减少、骨髓成熟巨核细胞增多，与模型组比较差异有统计学意义（P＜0.01）。结论氨磷汀对免疫性血小板减少性紫癜有较为明显的治疗效果。
　　목적탐토안린정대면역성혈소판감소성자전（ITP）동물모형소서혈소판、비장계수、골수거서세포적영향。방법통과획취BALB/C 소서혈소판항체，접충도돈서신상，획취돈서항소서혈소판항체（APS）。장APS복강주사BALB/C 소서건립면역성혈소판감소성자전동물모형，사용안린정복강주사진행치료，관찰안린정대모형소서적혈소판、비장계수、골수거서세포적영향。결과안린정급약후균사ITP모형소서혈소판계수상승、비장계수감소、골수성숙거핵세포증다，여모형조비교차이유통계학의의（P＜0.01）。결론안린정대면역성혈소판감소성자전유교위명현적치료효과。
Objective To study the effect of amifostine on mice models of idiopathic thrombocytopenic purpura(ITP). Methods Guinea pig anti mice platelet serum(GP-APS) was diluted with saline(1:4),and intravitreal injected into mice once in 2 days for 10 days.Two dosage of amifostine was intravitreal injected into mice in 10 days since mice models of ITP were established. Results Amifostine can enhance the amount of platelets,promote the mature of megakaryocyte of mice significantly and improve the histological pathology of spleen. Conclusion Amifostine is an effective and safety medicine in treating ITP, and can be used widely in clinic.