CAJ | 학술논문

　　目的比较氟尿嘧啶联合多西紫杉醇与氟尿嘧啶联合顺铂治疗老年晚期胃癌的疗效。方法将71例老年晚期胃癌按随机数字表法分为观察组（n=36）和对照组（n=35），对照组给予顺铂和氟尿嘧啶治疗，观察组给予多西紫杉醇与氟尿嘧啶治疗，治疗2个周期后观察其临床治疗效果和不良反应情况。结果观察组有效率为63.9%，对照组有效率为48.6%，差异具有统计学意义（P<0.05）。与治疗前比较，两组治疗后生活质量评分均有所提高，但是差异无统计学意义（P＞0.05）。两组患者主要表现为骨髓抑制和消化道反应，观察组不良反应更少，程度更轻。结论多西紫杉醇联合氟尿嘧啶治疗晚期胃癌有较好疗效，能减缓肿瘤的进展，改善其生存质量，药物毒副作用较轻。
　　목적비교불뇨밀정연합다서자삼순여불뇨밀정연합순박치료노년만기위암적료효。방법장71례노년만기위암안수궤수자표법분위관찰조（n=36）화대조조（n=35），대조조급여순박화불뇨밀정치료，관찰조급여다서자삼순여불뇨밀정치료，치료2개주기후관찰기림상치료효과화불량반응정황。결과관찰조유효솔위63.9%，대조조유효솔위48.6%，차이구유통계학의의（P<0.05）。여치료전비교，량조치료후생활질량평분균유소제고，단시차이무통계학의의（P＞0.05）。량조환자주요표현위골수억제화소화도반응，관찰조불량반응경소，정도경경。결론다서자삼순연합불뇨밀정치료만기위암유교호료효，능감완종류적진전，개선기생존질량，약물독부작용교경。
Objective To evaluate the efficacy and adverse effects of docetaxel combined with 5-fluorouracil in treating patients with advanced gastric cancer. Methods 71 patients with advanced gastric cancer were randomly divided into observation group and control group, observation group treated with docetaxel combined with 5- fluorouracil, the control group treated with 5-fluorouracil and cisplatin, the clinical efficacy after the treatment was observerd. Results The clinical efficiency rate of the observation group was significantly higher than that of the control group, the rate of leukopenia, thrombocytopenia and gastrointestinal reactions of the observation group was significantly lower than the control group, the quality of life scores of the two groups after treatment were al improved, but that of the observation group was significantly higher than the control group, the difference was statistical y significant(P<0.05). Conclusion Docetaxel combined with 5-fluorouracil was effective in treating advanced gastric cancer. It worth further clinical research and application.