医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2013年
22期
64-65
,共2页
羊江鸿%陈伟%林雪妹(通讯作者)
羊江鴻%陳偉%林雪妹(通訊作者)
양강홍%진위%림설매(통신작자)
高血压%硝苯地平%氯氨地平
高血壓%硝苯地平%氯氨地平
고혈압%초분지평%록안지평
hypertension%Amiodipine Besylate%nifedipine
目的探讨不同联合用药方式对老年高血压患者的降压效果。方法将2010年1月-2011年6月间在我院住院的老年高血压患者316人随机分为A、B两组，每组158人，A组患者降压方案为每日口服贝纳普利和氯氨地平，B组患者降压方案为每日口服贝纳普利和硝苯地平，连续服用8周，期间每天监测患者的收缩压降压幅度、舒张压降压幅度以判断临床疗效。组间数据利用SPSS13.0进行统计学分析。结果8周治疗结束后A、B两组舒张压的平均降压幅度为14.9mmHg和12.7mmHg，收缩压的降压幅度是32.9mmHg和29.7mmHg，统计学分析不具有显著差异（P=0.069>0.05）。治疗效果为显效、有效、无效及总有效的病例在A组中的比率分别为60.8%、291%、3.8%及96.2%，在B组中的比率分别为47.4%、44.9%、7.6%及92.4%。两组患者治疗总有效率的差异不具有统计学意义（P>0.05），但显效率的差异具有统计学意义（P<0.01）。结论氯氨地平和硝苯地平与贝纳普利的联用治疗高血压患者均具有较好疗效，但氯氨地平与贝纳普利的联用可显著提高患者的治疗效果。
目的探討不同聯閤用藥方式對老年高血壓患者的降壓效果。方法將2010年1月-2011年6月間在我院住院的老年高血壓患者316人隨機分為A、B兩組，每組158人，A組患者降壓方案為每日口服貝納普利和氯氨地平，B組患者降壓方案為每日口服貝納普利和硝苯地平，連續服用8週，期間每天鑑測患者的收縮壓降壓幅度、舒張壓降壓幅度以判斷臨床療效。組間數據利用SPSS13.0進行統計學分析。結果8週治療結束後A、B兩組舒張壓的平均降壓幅度為14.9mmHg和12.7mmHg，收縮壓的降壓幅度是32.9mmHg和29.7mmHg，統計學分析不具有顯著差異（P=0.069>0.05）。治療效果為顯效、有效、無效及總有效的病例在A組中的比率分彆為60.8%、291%、3.8%及96.2%，在B組中的比率分彆為47.4%、44.9%、7.6%及92.4%。兩組患者治療總有效率的差異不具有統計學意義（P>0.05），但顯效率的差異具有統計學意義（P<0.01）。結論氯氨地平和硝苯地平與貝納普利的聯用治療高血壓患者均具有較好療效，但氯氨地平與貝納普利的聯用可顯著提高患者的治療效果。
목적탐토불동연합용약방식대노년고혈압환자적강압효과。방법장2010년1월-2011년6월간재아원주원적노년고혈압환자316인수궤분위A、B량조，매조158인，A조환자강압방안위매일구복패납보리화록안지평，B조환자강압방안위매일구복패납보리화초분지평，련속복용8주，기간매천감측환자적수축압강압폭도、서장압강압폭도이판단림상료효。조간수거이용SPSS13.0진행통계학분석。결과8주치료결속후A、B량조서장압적평균강압폭도위14.9mmHg화12.7mmHg，수축압적강압폭도시32.9mmHg화29.7mmHg，통계학분석불구유현저차이（P=0.069>0.05）。치료효과위현효、유효、무효급총유효적병례재A조중적비솔분별위60.8%、291%、3.8%급96.2%，재B조중적비솔분별위47.4%、44.9%、7.6%급92.4%。량조환자치료총유효솔적차이불구유통계학의의（P>0.05），단현효솔적차이구유통계학의의（P<0.01）。결론록안지평화초분지평여패납보리적련용치료고혈압환자균구유교호료효，단록안지평여패납보리적련용가현저제고환자적치료효과。
Objective To investigate the antihypertensive effect of the combined medication in the treatment of the elderly patients with essential hypertension. Methods 316 elderly patients with hypertension were randomly divided into two groups of which group A was treated with Benazepril and Amiodipine Besylate,group B were treated with Benazepril and nifedipine. 8 weeks later, the systolic blood pressure and the diastolic blood pressure were detected and the reduced pressure amplitude were used to identify the treatment outcome. Al the data were analyzed by SPSS13.0. Results The mean reduced diastolic pressure amplitude in group A and B were 14.9mmHg and 12.7 mmHg , the mean reduced systolic pressure amplitude in group A and B were 32.9 mmHg and 29.7mmHg, which has no significantly difference between the two groups. The frequency of significant effective ,effective, invalid ,total effective cases is 60.8%、291%、3.8%、96.2% in group A, and 47.4%、44.9%、7.6%、92.4% in group B. The total effective frequency between the two groups is similar, while the significantly effective frequency between the two groups is statistical y different (P<0.01).Conclusion Both of the two CCB antihypertensive medicine is good when they are combined with Benazepril ,and the Amiodipine Besylate is better for the patients.
