浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2014年
7期
578-581
,共4页
李海洋%施晓%吕芸%孙运明%赵德珍
李海洋%施曉%呂蕓%孫運明%趙德珍
리해양%시효%려예%손운명%조덕진
子宫内膜异位症%肿瘤特异性生长因子%糖类抗原125
子宮內膜異位癥%腫瘤特異性生長因子%糖類抗原125
자궁내막이위증%종류특이성생장인자%당류항원125
Endometriosis%TSGF(tumor specific growth factor)%CA125
目的：探讨血清肿瘤特异性生长因子（TSGF）、糖类抗原125（CA125）水平对子宫内膜异位症（EMs）的诊断价值，及其与临床分期和疾病复发的相关性。方法选取经手术和病理检查确诊的EMs患者110例为研究组，同期体检的健康妇女127例为对照组。采用发光微粒子免疫检测法和生化光电比色法分别检测两组血清CA125、TSGF水平。结果研究组术前血清TSGF、CA125均高于对照组（均P＜0.01）；术后1个月较术前均下降（均P＜0.01），但仍高于对照组（均P＜0.01）；术后3个月继续下降，与对照组已无统计学差异（P＞0.05）。术后1年，5例复发者血清TSGF水平高于对照组（P＜0.05），而血清CA125水平与对照组差异无统计学意义（P＞0.05）。此外，Ⅲ、Ⅳ期EMs患者血清TSGF水平均高于对照组（均P＜0.01），且Ⅳ期高于Ⅲ期（P＜0.05）；Ⅲ、Ⅳ期患者血清CA125水平高于对照组（均P＜0.01），但Ⅲ、Ⅳ期差异无统计学意义（P＞0.05）。以TSGF≥64U/ml、CA125≥35U/ml为阳性临界值，两者平行试验诊断敏感度为80.9%，特异度为85.0%，诊断符合率为83.1%。结论联合检测血清TSGF和CA125能提高EMs诊断敏感度和特异度；且血清TSGF水平在中重度EMs患者中与r- AFS分期呈正相关；血清TSGF可单独作为一项监测复发的指标。
目的：探討血清腫瘤特異性生長因子（TSGF）、糖類抗原125（CA125）水平對子宮內膜異位癥（EMs）的診斷價值，及其與臨床分期和疾病複髮的相關性。方法選取經手術和病理檢查確診的EMs患者110例為研究組，同期體檢的健康婦女127例為對照組。採用髮光微粒子免疫檢測法和生化光電比色法分彆檢測兩組血清CA125、TSGF水平。結果研究組術前血清TSGF、CA125均高于對照組（均P＜0.01）；術後1箇月較術前均下降（均P＜0.01），但仍高于對照組（均P＜0.01）；術後3箇月繼續下降，與對照組已無統計學差異（P＞0.05）。術後1年，5例複髮者血清TSGF水平高于對照組（P＜0.05），而血清CA125水平與對照組差異無統計學意義（P＞0.05）。此外，Ⅲ、Ⅳ期EMs患者血清TSGF水平均高于對照組（均P＜0.01），且Ⅳ期高于Ⅲ期（P＜0.05）；Ⅲ、Ⅳ期患者血清CA125水平高于對照組（均P＜0.01），但Ⅲ、Ⅳ期差異無統計學意義（P＞0.05）。以TSGF≥64U/ml、CA125≥35U/ml為暘性臨界值，兩者平行試驗診斷敏感度為80.9%，特異度為85.0%，診斷符閤率為83.1%。結論聯閤檢測血清TSGF和CA125能提高EMs診斷敏感度和特異度；且血清TSGF水平在中重度EMs患者中與r- AFS分期呈正相關；血清TSGF可單獨作為一項鑑測複髮的指標。
목적：탐토혈청종류특이성생장인자（TSGF）、당류항원125（CA125）수평대자궁내막이위증（EMs）적진단개치，급기여림상분기화질병복발적상관성。방법선취경수술화병리검사학진적EMs환자110례위연구조，동기체검적건강부녀127례위대조조。채용발광미입자면역검측법화생화광전비색법분별검측량조혈청CA125、TSGF수평。결과연구조술전혈청TSGF、CA125균고우대조조（균P＜0.01）；술후1개월교술전균하강（균P＜0.01），단잉고우대조조（균P＜0.01）；술후3개월계속하강，여대조조이무통계학차이（P＞0.05）。술후1년，5례복발자혈청TSGF수평고우대조조（P＜0.05），이혈청CA125수평여대조조차이무통계학의의（P＞0.05）。차외，Ⅲ、Ⅳ기EMs환자혈청TSGF수평균고우대조조（균P＜0.01），차Ⅳ기고우Ⅲ기（P＜0.05）；Ⅲ、Ⅳ기환자혈청CA125수평고우대조조（균P＜0.01），단Ⅲ、Ⅳ기차이무통계학의의（P＞0.05）。이TSGF≥64U/ml、CA125≥35U/ml위양성림계치，량자평행시험진단민감도위80.9%，특이도위85.0%，진단부합솔위83.1%。결론연합검측혈청TSGF화CA125능제고EMs진단민감도화특이도；차혈청TSGF수평재중중도EMs환자중여r- AFS분기정정상관；혈청TSGF가단독작위일항감측복발적지표。
Objective To evaluate serum tumor specific growth factor (TSGF) and CA125 levels in diagnosis of en-dometriosis (EMs). Methods Serum TSGF and CA125 levels were determined by chemiluminescence microparticle immunoas-say(CMIA) and biochemical photoelectric colormetry (BPC) respectively in 110 patients with EMs and 127 healthy subjects. Re-sults The preoperative serum TSGF and CA125 levels in patients with EMs were significantly higher than those in controls (P<0.01). One month after operation, serum TSGF and CA125 levels were decreased significantly (P<0.01), whereas they were stil higher than those in controls(P<0.01). Three months after operation, serum TSGF and CA125 levels dropped as in controls (P>0.05). One year after treatment, TSGF levels in 5 relapse patients were higher than those in controls (P<0.01), while there was no difference in CA125 levels (P>0.05). Moreover, serum TSGF levels in stage III, IV of EMs were significantly higher than those in controls (P<0.01), and TSGF level in stage IV was higher than that in stage III (P<0.05). Serum CA125 levels in stage III, IV were higher than those in controls (P<0.01), but there was no difference between stages III and IV (P>0.05). Taking 64U/ml of TSGF, 35U/ml of CA125 cut- off values, the sensitivity for diagnosis of EMs was 80.9%, specificity was 85.0%, and the diagnostic accor-dance rate was 83.1%. Conclusion The sensitivity and specificity of serum TSGF combined with CA125 are satisfactory in diag-nosis of EMs. Serum TSGF level is positively correlated with r- AFS stages of EMs, and can be used for early detection of relapse in patients with EMs.
