中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
9期
1287-1288
,共2页
徐慧芳%李道成%王淑平%黄敏珊
徐慧芳%李道成%王淑平%黃敏珊
서혜방%리도성%왕숙평%황민산
卡前列甲酯栓%催产素%高危产妇%产后出血
卡前列甲酯栓%催產素%高危產婦%產後齣血
잡전렬갑지전%최산소%고위산부%산후출혈
Methylcarprost suppositories%Oxytocin%High-risk maternal%Postpartum hemorrhage
目的 观察卡前列甲酯栓配伍催产素预防阴道分娩高危产妇产后出血的临床效果.方法 将足月阴道分娩高危产妇400例完全随机分为观察组和对照组,各200例.观察组高危产妇于胎儿娩出后,肌内注射催产素20 U,并给予卡前列甲酯栓l mg塞肛；对照组仅肌内注射催产素20.U.观察2组产妇第三产程时间及产后2、24h出血量和产后出血发生率,以及用药后血压、脉搏的变化及药物不良反应.结果 观察组第三产程时间、产后2h出血量、产后24h出血量及产后出血发生率均明显少于对照组[(7.6±2.8)min比(11.5±2.9) min,(196±45) ml比(304±38) ml,(256±50) ml比(379±44)ml,3.5％ (7/200)比10.5％(21/200)],差异均有统计学意义(均P＜0.05).2组产妇治疗前后血压、脉搏差异无统计学意义(P＞0.05).观察组有10例出现轻微腹泻,3例出血、恶心,对照组未出现明显不良反应.结论 卡前列甲酯栓配伍催产素对预防及减少高危产妇产后出血安全、有效.
目的 觀察卡前列甲酯栓配伍催產素預防陰道分娩高危產婦產後齣血的臨床效果.方法 將足月陰道分娩高危產婦400例完全隨機分為觀察組和對照組,各200例.觀察組高危產婦于胎兒娩齣後,肌內註射催產素20 U,併給予卡前列甲酯栓l mg塞肛；對照組僅肌內註射催產素20.U.觀察2組產婦第三產程時間及產後2、24h齣血量和產後齣血髮生率,以及用藥後血壓、脈搏的變化及藥物不良反應.結果 觀察組第三產程時間、產後2h齣血量、產後24h齣血量及產後齣血髮生率均明顯少于對照組[(7.6±2.8)min比(11.5±2.9) min,(196±45) ml比(304±38) ml,(256±50) ml比(379±44)ml,3.5％ (7/200)比10.5％(21/200)],差異均有統計學意義(均P＜0.05).2組產婦治療前後血壓、脈搏差異無統計學意義(P＞0.05).觀察組有10例齣現輕微腹瀉,3例齣血、噁心,對照組未齣現明顯不良反應.結論 卡前列甲酯栓配伍催產素對預防及減少高危產婦產後齣血安全、有效.
목적 관찰잡전렬갑지전배오최산소예방음도분면고위산부산후출혈적림상효과.방법 장족월음도분면고위산부400례완전수궤분위관찰조화대조조,각200례.관찰조고위산부우태인면출후,기내주사최산소20 U,병급여잡전렬갑지전l mg새항；대조조부기내주사최산소20.U.관찰2조산부제삼산정시간급산후2、24h출혈량화산후출혈발생솔,이급용약후혈압、맥박적변화급약물불량반응.결과 관찰조제삼산정시간、산후2h출혈량、산후24h출혈량급산후출혈발생솔균명현소우대조조[(7.6±2.8)min비(11.5±2.9) min,(196±45) ml비(304±38) ml,(256±50) ml비(379±44)ml,3.5％ (7/200)비10.5％(21/200)],차이균유통계학의의(균P＜0.05).2조산부치료전후혈압、맥박차이무통계학의의(P＞0.05).관찰조유10례출현경미복사,3례출혈、악심,대조조미출현명현불량반응.결론 잡전렬갑지전배오최산소대예방급감소고위산부산후출혈안전、유효.
Objective To observe the clinical effect of carboprost methylate suppository combined with oxytocin on prevention of high-risk maternal postplartum hemorrhage after transvaginal delivery.Methods All 400 transvaginal delivery high-risk maternal were randomly divided into control group and observation group(200 cases each group).The control group after delivery were given oxytocin 20 U by intramuscular injection.On the basis of the control group,the observation group put another 1 mg carboprost mertrylate suppositroies into rectum.The minutes of the third stage of labor,the hemorrhage quantity at 2,24 h after deliver,the incidence rate of postpartum hemorrhage,blood pressure,pulse rate and adverse reaction were observed.Results The minutes of the third stage of labor,postpartum hemorrhage volume in 2,24 h after deliver and the incidence of postpartum hemorrhage in observation group were significantly lower than the control group [(7.6 ± 2.8) min vs (11.5 ± 2.9) min,(196 ± 45) ml vs (304 ±38)m1,(256 ±50)ml vs(379 ±44)ml,3.5％ (7/200) vs t0.5％ (21/200),P ＜0.05].Ten cases had mild diarrhea and 3 cases had nausea in observation group,while there were no obvious adverse reaction in control group.Connclusion The efficacy of carboprost combined with oxytocin in prevention of high-risk maternal postpartum hemorrhage is safe and efficient.
