CAJ | 학술논문

采用微粒子增强比浊法检测114例2型糖尿病不伴视网膜病变患者(A组)和105例2型糖尿病伴视网膜病变患者(B组)血清胱抑素C水平,并选47名正常健康者作为对照组(NC组).结果显示,B组血清胱抑素C水平明显高于NC组和A组(均P＜0.05),A组与NC组间血清胱抑素C水平无统计学差异；Logistic多元逐步回归分析表明血清胱抑素C、胆固醇和收缩压是影响2型糖尿病患者视网膜病变发生的独立危险因素(均P＜0.05),提示检测血清胱抑素C水平对糖尿病视网膜病变的早期诊断和防治可能具有一定的临床指导意义.
채용미입자증강비탁법검측114례2형당뇨병불반시망막병변환자(A조)화105례2형당뇨병반시망막병변환자(B조)혈청광억소C수평,병선47명정상건강자작위대조조(NC조).결과현시,B조혈청광억소C수평명현고우NC조화A조(균P＜0.05),A조여NC조간혈청광억소C수평무통계학차이；Logistic다원축보회귀분석표명혈청광억소C、담고순화수축압시영향2형당뇨병환자시망막병변발생적독립위험인소(균P＜0.05),제시검측혈청광억소C수평대당뇨병시망막병변적조기진단화방치가능구유일정적림상지도의의.
[Summary] Serum cystatin C levels were measured by microparticle enhanced turbidimetry in 114 type 2diabetic patients without retinopathy (group A) and 105 type 2 diabetic patients with retinopathy (group B),as well as 47 normal healthy individuals as controls (group NC).The results showed that the serum cystatin C level of group B was much higher than those of group NC and group A (P＜0.05).However,there was no difference in serum cystatin C level between group NC and group A.Multivariate logistic regression analysis revealed that serum levels of cystatin C and cholesterol,and systemic blood pressure were independent risk factors of diabetic retinopathy in type 2 diabetic patients (all P＜0.05),suggesting that detection of serum cystatin C level may play an important role in early diagnosis and prevention of diabetic retinopathy.