CAJ | 학술논문

目的：观察乳癌组织中C-MYC和MXI1蛋白表达状况，探讨其临床意义。方法：应用免疫组化SP法检测132例乳癌和20例正常乳腺组织中C-MYC和MXI1蛋白的表达情况，并分析其与临床病理特征的关系。结果：乳癌组织中 C-MYC 和MXI1的阳性表达率分别为57．6％和50．0％，均明显高于正常乳腺组织（χ2＝12．613、14．269， P均＜0．001）。组织学分级高、雌激素受体（ER）和孕激素受体（PR）均阴性以及Ki-67阳性的乳癌组织中C-MYC蛋白阳性表达率较高（χ2＝9．135、8．188、7．816， P均＜0．05），而MXI1蛋白阳性表达率较低（χ2＝7．822、8．123、8．381， P均＜0．05）。乳癌组织中C-MYC和MXI1蛋白表达呈负关联（rp ＝-0．182，P＝0．035）。 C-MYC阴性和阳性者、MXI1阴性和阳性者的生存曲线差异均有统计学意义（χ2＝14．597、22．556， P均＜0．05），C-MYC阴性者中位生存时间较C-MYC阳性者延长（55．98个月 vs 46．34个月），MXI1阳性者中位生存时间较MXI1阴性者延长（56．26个月vs 44．61个月）。结论：C-MYC表达上调和MXI1表达下调可能与乳癌的发生、发展有关。
목적：관찰유암조직중C-MYC화MXI1단백표체상황，탐토기림상의의。방법：응용면역조화SP법검측132례유암화20례정상유선조직중C-MYC화MXI1단백적표체정황，병분석기여림상병리특정적관계。결과：유암조직중 C-MYC 화MXI1적양성표체솔분별위57．6％화50．0％，균명현고우정상유선조직（χ2＝12．613、14．269， P균＜0．001）。조직학분급고、자격소수체（ER）화잉격소수체（PR）균음성이급Ki-67양성적유암조직중C-MYC단백양성표체솔교고（χ2＝9．135、8．188、7．816， P균＜0．05），이MXI1단백양성표체솔교저（χ2＝7．822、8．123、8．381， P균＜0．05）。유암조직중C-MYC화MXI1단백표체정부관련（rp ＝-0．182，P＝0．035）。 C-MYC음성화양성자、MXI1음성화양성자적생존곡선차이균유통계학의의（χ2＝14．597、22．556， P균＜0．05），C-MYC음성자중위생존시간교C-MYC양성자연장（55．98개월 vs 46．34개월），MXI1양성자중위생존시간교MXI1음성자연장（56．26개월vs 44．61개월）。결론：C-MYC표체상조화MXI1표체하조가능여유암적발생、발전유관。
Aim:To investigate the expressions of C-MYC and MXI1 protein in breast cancer tissue .Methods:The expressions of C-MYC and MXI1 in 132 cases of breast cancer and 20 cases of normal breast tissue were detected by immu-nohistochemistry .The relationship between the expressions of the two proteins and the clinical characters was analyzed . Results:The positive expression rates of C-MYC and MXI1 in breast cancer tissue (57.6% and 50.0%, respectively) were obviously higher than those in normal breast tissue (χ2 =12.613,14.269,P<0.001).In the breast cancer tissue with high histological grade, negative expression of estrogen receptor (ER) and progesterone receptor(PR), or positive expres-sion of Ki-67,the C-MYC expression was higher(χ2 =9.135,8.188,7.816, P<0.05), and the MXI1 expression was low-er(χ2 =7.822,8.123,8.381, P<0.05).The C-MYC expression in breast cancer tissue was negatively related to that of MXI1(rp =-0.182,P=0.035).There were significant differences in the survival curves between C-MYC or MXI1 posi-tive and negative patients(χ2 =14.597,22.556,P<0.05).The median survival time of C-MYC negative or MXI1 positive patients(55.98 and 56.26 months,respectively) was longer than C-MYC positive or MXI1 negative patients(46.34 and 44.61 months,respectively).Conclusion:The up-regulated expression of C-MYC and down-regulated expression of MXI1 may be related to the carcinogenesis and development of breast cancer .