国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2014年
2期
185-188
,共4页
刘小兰%麦惠容%李长钢%王缨%刘四喜%袁秀丽%文飞球
劉小蘭%麥惠容%李長鋼%王纓%劉四喜%袁秀麗%文飛毬
류소란%맥혜용%리장강%왕영%류사희%원수려%문비구
急性淋巴细胞白血病%无事件生存率%儿童
急性淋巴細胞白血病%無事件生存率%兒童
급성림파세포백혈병%무사건생존솔%인동
Acute,lymphoblastic,Leukemia%Children%Event-free survival
目的 分析初诊儿童急性淋巴细胞白血病的临床特征及远期疗效情况,提高急性淋巴细胞白血病患儿的总生存率(overall survival,OS)和无事件生存率(event-free survival,EFS).方法 收集2005年至2010年住院治疗的初诊急性淋巴细胞白血病80例患儿的临床资料,采用急性淋巴细胞白血病IC-BFM2002为基础的化疗方案,运用Kaplan-Meier法统计分析患儿的5年OS和EFS.结果 80例患儿,男女比例1.22∶1,中位年龄4岁3个月,标危33例(41.2％),中危37例(46.3％),高危10例(12.5％),白细胞(WBC≥20×109/L)22例(27.5％),BCR/ABL阳性3例(3.8％);MLL基因重排1例(1.3％);TEL/AML阳性17例(21.3％).完全缓解79例(98.8％),5年OS和EFS分别为(85.9±4.0)％和(79.2±4.7)％,其中标危组5年EFS(86.6±6.4)％,中危组5年EFS (81.1±6.4)％,高危组5年EFS(48.0±16.4)％,组间比较差异有统计学意义(x2=7.03,P＜0.05).复发12例(15.o％),中位时间23.5个月.死亡11例(13.8％),中位时间13个月.结论 初诊儿童急性淋巴细胞白血病患儿的疗效好,标准的分型诊断及危险度分层治疗有利于提高患儿的生存质量.
目的 分析初診兒童急性淋巴細胞白血病的臨床特徵及遠期療效情況,提高急性淋巴細胞白血病患兒的總生存率(overall survival,OS)和無事件生存率(event-free survival,EFS).方法 收集2005年至2010年住院治療的初診急性淋巴細胞白血病80例患兒的臨床資料,採用急性淋巴細胞白血病IC-BFM2002為基礎的化療方案,運用Kaplan-Meier法統計分析患兒的5年OS和EFS.結果 80例患兒,男女比例1.22∶1,中位年齡4歲3箇月,標危33例(41.2％),中危37例(46.3％),高危10例(12.5％),白細胞(WBC≥20×109/L)22例(27.5％),BCR/ABL暘性3例(3.8％);MLL基因重排1例(1.3％);TEL/AML暘性17例(21.3％).完全緩解79例(98.8％),5年OS和EFS分彆為(85.9±4.0)％和(79.2±4.7)％,其中標危組5年EFS(86.6±6.4)％,中危組5年EFS (81.1±6.4)％,高危組5年EFS(48.0±16.4)％,組間比較差異有統計學意義(x2=7.03,P＜0.05).複髮12例(15.o％),中位時間23.5箇月.死亡11例(13.8％),中位時間13箇月.結論 初診兒童急性淋巴細胞白血病患兒的療效好,標準的分型診斷及危險度分層治療有利于提高患兒的生存質量.
목적 분석초진인동급성림파세포백혈병적림상특정급원기료효정황,제고급성림파세포백혈병환인적총생존솔(overall survival,OS)화무사건생존솔(event-free survival,EFS).방법 수집2005년지2010년주원치료적초진급성림파세포백혈병80례환인적림상자료,채용급성림파세포백혈병IC-BFM2002위기출적화료방안,운용Kaplan-Meier법통계분석환인적5년OS화EFS.결과 80례환인,남녀비례1.22∶1,중위년령4세3개월,표위33례(41.2％),중위37례(46.3％),고위10례(12.5％),백세포(WBC≥20×109/L)22례(27.5％),BCR/ABL양성3례(3.8％);MLL기인중배1례(1.3％);TEL/AML양성17례(21.3％).완전완해79례(98.8％),5년OS화EFS분별위(85.9±4.0)％화(79.2±4.7)％,기중표위조5년EFS(86.6±6.4)％,중위조5년EFS (81.1±6.4)％,고위조5년EFS(48.0±16.4)％,조간비교차이유통계학의의(x2=7.03,P＜0.05).복발12례(15.o％),중위시간23.5개월.사망11례(13.8％),중위시간13개월.결론 초진인동급성림파세포백혈병환인적료효호,표준적분형진단급위험도분층치료유리우제고환인적생존질량.
Objective To analysis the clinical characteristics and the long-term effect of children with acute lymphoblastic leukemia (ALL).Methods From 2005 to 2010,80 newly diagnosed ALL children were enrolled and treated with protocol based on ALL-BFM2002.The five-years overall survival (OS)and event-free survival(EFS) were analyzed by the method of Kaplan-Meier.Results For the 80 patients,male to female ratio is 1.22∶1.The median age was 4.3 years.33 were in standard risk(41.2％),37 were in medium risk(46.3％),and 10 were in high risk(12.5％).22 had white blood cell count ≥20 x 109/L(27.5％).three patients with BCR-ABL translocation(3.8％),one patient with MLL gene rearrangement(1.3％),17 patients with TEL-AML translocation (21.3％).During induction therapy,79 patients (98.8 ％) achieved complete remission(CR).The five-years OS and EFS were (85.9 ± 4.0) ％ and (79.2 ± 4.7) ％ respectively.The five-years EFS:SR group (86.6 ± 6.4) ％,IR group (81.1 ± 6.4) ％,HR group (48.0 ± 16.4) ％.The difference among risk groups was statistically significant(x2 =7.03,P ＜0.05).12 patients relapsed(15.0％),the median time from diagnosis to relapse was 23.5 months.11 patients died (13.8 ％).Conclusion According to stratification by risk factors and risk-adapted therapy,the quality of ALL children's life had improved.
