CAJ | 학술논문

目的探讨周疗法去铁治疗输血相关性慢性铁超负荷的临床应用及疗效.方法以20例慢性铁超负荷患者为研究对象,回顾性分析周疗法静脉滴注铁螯合剂去铁胺治疗输血相关性铁超负荷患者的去铁效果及治疗前后肝功能、胰腺功能情况.结果治疗6个月后,患者血清铁蛋白(SF)水平为(2693.7±709.9) μg/L,较治疗前的(2771.5±725.2)μg/L无明显变化,但临床症状明显减轻；治疗12个月后,SF水平为(2083.7±714.4) μg/L,与治疗前水平比较差异有统计学意义(t=3.35,P＜ 0.01),其中16例患者下降明显；7例患者治疗后肝功能改善；5例胰腺功能好转,血糖下降.结论应用去铁胺周疗法治疗慢性铁超负荷患者能降低血清SF水平,且可使受损脏器的功能得到改善.
목적 탐토주요법거철치료수혈상관성만성철초부하적림상응용급료효.방법 이20례만성철초부하환자위연구대상,회고성분석주요법정맥적주철오합제거철알치료수혈상관성철초부하환자적거철효과급치료전후간공능、이선공능정황.결과 치료6개월후,환자혈청철단백(SF)수평위(2693.7±709.9) μg/L,교치료전적(2771.5±725.2)μg/L무명현변화,단림상증상명현감경；치료12개월후,SF수평위(2083.7±714.4) μg/L,여치료전수평비교차이유통계학의의(t=3.35,P＜ 0.01),기중16례환자하강명현；7례환자치료후간공능개선；5례이선공능호전,혈당하강.결론 응용거철알주요법치료만성철초부하환자능강저혈청SF수평,차가사수손장기적공능득도개선.
Objective To explore the clinical application and curative effect of iron removal treatment with week-therapy in chronic iron overload related to blood transfusion.Methods Twenty patients who were diagnosed as chronic iron overload were retrospectively studied.The amelioration of liver and pancreatic fanctions in patients with chronic iron overload treated with week-therapy of iron chelating agent through intravenous drip.Results The changes in the level of serum ferritin [2693.7±709.9) μg/L] were not significant after treatment at six months,hut the cilinical symptoms were relieved obviously.The levels of serum ferritin in patients after the treatment at twelve months were significantly different from the level before treated [(2083.7±714.4) μg/L vs (2771.5±725.2) μg/L,t =3.35,P ＜ 0.01],and the decreases were significant in sixteen patients.The liver functions in seven patients were improved and pancreatic functions were better in five patients.Conclusion The study suggests that iron removal treatment with week-therapy is effective for chronic iron overload,and improves the functions of damaged organs.