中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
1期
90-92
,共3页
邓海燕%杨进琼%卢少红%蔡浩然
鄧海燕%楊進瓊%盧少紅%蔡浩然
산해연%양진경%로소홍%채호연
多囊卵巢综合征%肥胖症%葡萄糖代谢紊乱%胰岛素
多囊卵巢綜閤徵%肥胖癥%葡萄糖代謝紊亂%胰島素
다낭란소종합정%비반증%포도당대사문란%이도소
Polycystic ovary syndrome%Obesity%Glucose metabolism disorders%Insulin
目的 探讨非肥胖型和肥胖型多囊卵巢综合征(PCOS)患者的糖代谢特征.方法 回顾性分析2008年3月至2011年7月就诊的118例PCOS患者的临床资料,以及糖耐量、胰岛素释放试验的结果,按体质量指数(BMI)分为非肥胖组65例(BMI＜ 25 kg/m2)和肥胖组53例(BMI≥25 kg/m2),比较两组患者口服糖耐量试验(OGTT)结果,以及空腹血糖调节受损(IFG)、糖耐量减低(IGT)和2型糖尿病的发生率.结果 (1)血糖水平:空腹及服糖后30、60、120、180 min,非肥胖组分别为(5.2±1.1)、(8.5±2.8)、(8.1±2.4)、(6.3±2.0)、(4.8±1.5) mmol/L,肥胖组分别为(5.4±0.9)、(9.1±1.8)、(9.3±0.6)、(7.6±1.0)、(5.4±0.8) mmol/L,两组各时间点血糖水平比较,差异均有统计学意义(t值分别为-6.125、-4.005、-6.074、-6.751、-4.512,P均＜0.01).(2)胰岛素水平:空腹及服糖后30、60、120 min,非肥胖组分别为(8±4)、(55±21)、(65±14)、(45±18) mU/L,肥胖组分别为(13±8)、(85 ±30)、(105±54)、(76±46) mU/L,两组各时间点比较,差异均有统计学意义(t值分别为-17.024、-12.540、-15.791、-16.149,P均＜0.01)；但服糖后180m in两组胰岛素水平比较,差异无统计学意义(P＞0.05).(3)糖代谢异常发生率:非肥胖组和肥胖组分别为13.85％(9/65)和24.53％ (13/53),两组比较差异有统计学意义(x2 =18.446,P＜0.01)；非肥胖组和肥胖组2型糖尿病发生率分别为1.54％(1/65)和7.55％(4/53),两组比较差异也有统计学意义(x2=16.005,P＜0.01).结论 肥胖型较非肥胖型PCOS患者更易发生糖代谢紊乱.
目的 探討非肥胖型和肥胖型多囊卵巢綜閤徵(PCOS)患者的糖代謝特徵.方法 迴顧性分析2008年3月至2011年7月就診的118例PCOS患者的臨床資料,以及糖耐量、胰島素釋放試驗的結果,按體質量指數(BMI)分為非肥胖組65例(BMI＜ 25 kg/m2)和肥胖組53例(BMI≥25 kg/m2),比較兩組患者口服糖耐量試驗(OGTT)結果,以及空腹血糖調節受損(IFG)、糖耐量減低(IGT)和2型糖尿病的髮生率.結果 (1)血糖水平:空腹及服糖後30、60、120、180 min,非肥胖組分彆為(5.2±1.1)、(8.5±2.8)、(8.1±2.4)、(6.3±2.0)、(4.8±1.5) mmol/L,肥胖組分彆為(5.4±0.9)、(9.1±1.8)、(9.3±0.6)、(7.6±1.0)、(5.4±0.8) mmol/L,兩組各時間點血糖水平比較,差異均有統計學意義(t值分彆為-6.125、-4.005、-6.074、-6.751、-4.512,P均＜0.01).(2)胰島素水平:空腹及服糖後30、60、120 min,非肥胖組分彆為(8±4)、(55±21)、(65±14)、(45±18) mU/L,肥胖組分彆為(13±8)、(85 ±30)、(105±54)、(76±46) mU/L,兩組各時間點比較,差異均有統計學意義(t值分彆為-17.024、-12.540、-15.791、-16.149,P均＜0.01)；但服糖後180m in兩組胰島素水平比較,差異無統計學意義(P＞0.05).(3)糖代謝異常髮生率:非肥胖組和肥胖組分彆為13.85％(9/65)和24.53％ (13/53),兩組比較差異有統計學意義(x2 =18.446,P＜0.01)；非肥胖組和肥胖組2型糖尿病髮生率分彆為1.54％(1/65)和7.55％(4/53),兩組比較差異也有統計學意義(x2=16.005,P＜0.01).結論 肥胖型較非肥胖型PCOS患者更易髮生糖代謝紊亂.
목적 탐토비비반형화비반형다낭란소종합정(PCOS)환자적당대사특정.방법 회고성분석2008년3월지2011년7월취진적118례PCOS환자적림상자료,이급당내량、이도소석방시험적결과,안체질량지수(BMI)분위비비반조65례(BMI＜ 25 kg/m2)화비반조53례(BMI≥25 kg/m2),비교량조환자구복당내량시험(OGTT)결과,이급공복혈당조절수손(IFG)、당내량감저(IGT)화2형당뇨병적발생솔.결과 (1)혈당수평:공복급복당후30、60、120、180 min,비비반조분별위(5.2±1.1)、(8.5±2.8)、(8.1±2.4)、(6.3±2.0)、(4.8±1.5) mmol/L,비반조분별위(5.4±0.9)、(9.1±1.8)、(9.3±0.6)、(7.6±1.0)、(5.4±0.8) mmol/L,량조각시간점혈당수평비교,차이균유통계학의의(t치분별위-6.125、-4.005、-6.074、-6.751、-4.512,P균＜0.01).(2)이도소수평:공복급복당후30、60、120 min,비비반조분별위(8±4)、(55±21)、(65±14)、(45±18) mU/L,비반조분별위(13±8)、(85 ±30)、(105±54)、(76±46) mU/L,량조각시간점비교,차이균유통계학의의(t치분별위-17.024、-12.540、-15.791、-16.149,P균＜0.01)；단복당후180m in량조이도소수평비교,차이무통계학의의(P＞0.05).(3)당대사이상발생솔:비비반조화비반조분별위13.85％(9/65)화24.53％ (13/53),량조비교차이유통계학의의(x2 =18.446,P＜0.01)；비비반조화비반조2형당뇨병발생솔분별위1.54％(1/65)화7.55％(4/53),량조비교차이야유통계학의의(x2=16.005,P＜0.01).결론 비반형교비비반형PCOS환자경역발생당대사문란.
Objective To investigate characteristics of glucose metabolism of non-obese and obese women with polycystie ovary syndrome(PCOS).Methods From March 2008 to July 2011,118 PCOS patients were enrolled in this study and were divided into 53 cases (body mass index(BMI) ≥25 kg/m2) in obese group and 65 cases (BMI ＜ 25 kg/m2) in non-obese group.Participants' clinical data,glucose tolerance and insulin release test results were retrospectively reviewed.The prevalence of type 2 diabetes mellitus (T2DM),results of oral glucose tolerance test,impaired fasting glucose (IFG),impaired glucose tolerance (IGT) were compared between the two groups.Results (1) Blood glucose levels:at the time points of 30,60,120 and 180 minutes,the levels of fasting glucose were (5.2 ± 1.1),(8.5 ± 2.8),(8.1 ± 2.4),(6.3 ± 2.0) and (4.8 ± 1.5)mmol/L in non-obese group and(5.4 ±0.9),(9.1 ± 1.8),(9.3 ±0.6),(7.6 ± 1.0) and (5.4 ±0.8) mmol/L in obese group.Statistical difference was observed between obese and non-obese groups at each time point (t =-6.125,-4.005,-6.074,-6.751 and-4.512 respectively,P ＜0.01).(2) The level of insulin:at the time points of 30,60 and 120 min,the level of fasting insulin were (8 ± 4),(55 ± 21),(65 ± 14) and (45 ±18)mU/L in non-obese group and (13 ± 8),(85± 30),(105± 54) and (76 ± 46)mU/L in obese group.There were significant statistical difference between the two groups at each time point (t =-17.024,-12.540,-15.791 and-16.149 respectively,P ＜ 0.01).However,at the time point of 180 minutes,the level of insulin did not exhibit significant difference between obese and non-obese groups (P ＞ 0.05).(3) The prevalence of abnormal glucose metabolism:The rates of IGT were 13.85 ％ (9/65) in non-obese group and 24.53 ％ (13/53)in obese group,which also showed remarkable difference (x2 =18.446,P ＜ 0.01).The rates of T2DM were 1.54％ (1/65) in non-obese group and 7.55％ (4/53) in obese group,which reached significant difference (x2=16.005,P ＜ 0.01).Conclusion Abnormal glucose metabolism was observed more frequently in overweight or obese PCOS women.
