含噻唑环的肽脱甲酰基酶抑制剂的设计与合成
함새서배적태탈갑선기매억제제적설계여합성
Design and Synthesis Thiazole- bearing Compounds as PDF Inhibitors
  • 万方数据
    济宁学院学报 제저학원학보
    JOURNAL OF JINING UNIVERSITY
    2012年 3期 26-30 ,共5页

    尹玲%王影影%赵广旺

    윤령%왕영영%조엄왕

    肽脱甲酰基酶%抑制剂%BB-3497%噻唑%合成 肽脫甲酰基酶%抑製劑%BB-3497%噻唑%閤成
    태탈갑선기매%억제제%BB-3497%새서%합성
    peptide deformylase%inhibitor%BB - 3497%thiazole%synthesis
    以丙二酸二乙酯为原料经过多步反应，设计并合成了6个含噻唑环的肽脱甲酰基酶（PDF）抑制剂，利用1HNMR和HR—MS表征了它们的结构．
    이병이산이을지위원료경과다보반응，설계병합성료6개함새서배적태탈갑선기매（PDF）억제제，이용1HNMR화HR—MS표정료타문적결구．
    Six thiazole - bearing compounds were designed and synthesized through a multi - step protocol starting from diethyl malonate as peptide deformylase （PDF） inhibitors, and characterized by 1H NMR, HR - MS techniques.
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