中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
z1期
49-52
,共4页
王金生%唐容辉%周永江%杨轶敏
王金生%唐容輝%週永江%楊軼敏
왕금생%당용휘%주영강%양질민
慢性阻塞性肺疾病%丹参多酚酸盐%凝血%D-二聚体
慢性阻塞性肺疾病%丹參多酚痠鹽%凝血%D-二聚體
만성조새성폐질병%단삼다분산염%응혈%D-이취체
Chronic obstructive pulmonary disease%Depside salt from salvia miltiorrhiza%Coagulation%D-dimer
目的 探讨慢性阻塞性肺疾病急性加重期(AECOPD)凝血功能及血液流变学的变化及丹参多酚酸盐对其影响.方法 90例AECOPD患者按随机数字表法分为两组:常规治疗组(45例)采用常规治疗,丹参多酚酸盐治疗组(45例)在常规治疗的基础上加用丹参多酚酸盐静脉滴注,治疗14d后检测两组凝血4项及D-二聚体(D-dimer)的变化.同时选择健康者作为健康对照组(30例).结果 治疗前丹参多酚酸盐治疗组和常规治疗组Fbg和D-dimer水平明显高于健康对照组(P＜0.01).治疗14d后,常规治疗组血浆Fbg和D-dimer水平稍低于治疗前,但差异无统计学意义(P＞0.05).丹参多酚酸盐治疗组治疗14d后血浆Fbg和D-dimer水平明显低于治疗前(P＜0.05),并且与常规治疗治疗组治疗后比较差异有统计学意义(P＜0.05).而PT、APTT、TT水平在三组之间比较差异无统计学意义(P＞0.05).丹参多酚酸盐治疗组治疗后全血高切黏度[(4.76±1.35) mPa.S]、全血低切黏度[(8.69±2.36) mPa.S]、血浆黏度[(1.83±0.34) mPa.S]、红细胞压积[(40.3±2.38)％]明显低于常规治疗组[分别为(5.50.3±1.34)mPa.S、(12.30±2.30) mPa.S、(2.32±0.26) mPa.S、(47.89±3.13)％](P＜0.05).结论 AECOPD患者体内处于高凝状态,丹参多酚酸盐可改善AECOPD患者体内处于高凝状态.
目的 探討慢性阻塞性肺疾病急性加重期(AECOPD)凝血功能及血液流變學的變化及丹參多酚痠鹽對其影響.方法 90例AECOPD患者按隨機數字錶法分為兩組:常規治療組(45例)採用常規治療,丹參多酚痠鹽治療組(45例)在常規治療的基礎上加用丹參多酚痠鹽靜脈滴註,治療14d後檢測兩組凝血4項及D-二聚體(D-dimer)的變化.同時選擇健康者作為健康對照組(30例).結果 治療前丹參多酚痠鹽治療組和常規治療組Fbg和D-dimer水平明顯高于健康對照組(P＜0.01).治療14d後,常規治療組血漿Fbg和D-dimer水平稍低于治療前,但差異無統計學意義(P＞0.05).丹參多酚痠鹽治療組治療14d後血漿Fbg和D-dimer水平明顯低于治療前(P＜0.05),併且與常規治療治療組治療後比較差異有統計學意義(P＜0.05).而PT、APTT、TT水平在三組之間比較差異無統計學意義(P＞0.05).丹參多酚痠鹽治療組治療後全血高切黏度[(4.76±1.35) mPa.S]、全血低切黏度[(8.69±2.36) mPa.S]、血漿黏度[(1.83±0.34) mPa.S]、紅細胞壓積[(40.3±2.38)％]明顯低于常規治療組[分彆為(5.50.3±1.34)mPa.S、(12.30±2.30) mPa.S、(2.32±0.26) mPa.S、(47.89±3.13)％](P＜0.05).結論 AECOPD患者體內處于高凝狀態,丹參多酚痠鹽可改善AECOPD患者體內處于高凝狀態.
목적 탐토만성조새성폐질병급성가중기(AECOPD)응혈공능급혈액류변학적변화급단삼다분산염대기영향.방법 90례AECOPD환자안수궤수자표법분위량조:상규치료조(45례)채용상규치료,단삼다분산염치료조(45례)재상규치료적기출상가용단삼다분산염정맥적주,치료14d후검측량조응혈4항급D-이취체(D-dimer)적변화.동시선택건강자작위건강대조조(30례).결과 치료전단삼다분산염치료조화상규치료조Fbg화D-dimer수평명현고우건강대조조(P＜0.01).치료14d후,상규치료조혈장Fbg화D-dimer수평초저우치료전,단차이무통계학의의(P＞0.05).단삼다분산염치료조치료14d후혈장Fbg화D-dimer수평명현저우치료전(P＜0.05),병차여상규치료치료조치료후비교차이유통계학의의(P＜0.05).이PT、APTT、TT수평재삼조지간비교차이무통계학의의(P＞0.05).단삼다분산염치료조치료후전혈고절점도[(4.76±1.35) mPa.S]、전혈저절점도[(8.69±2.36) mPa.S]、혈장점도[(1.83±0.34) mPa.S]、홍세포압적[(40.3±2.38)％]명현저우상규치료조[분별위(5.50.3±1.34)mPa.S、(12.30±2.30) mPa.S、(2.32±0.26) mPa.S、(47.89±3.13)％](P＜0.05).결론 AECOPD환자체내처우고응상태,단삼다분산염가개선AECOPD환자체내처우고응상태.
Objective To investigate the changes of coagulation function and blood rheology in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and effects of depside salt from salvia miltiorrhiza.Methods The patients with AECOPD were randomly divided into depside salt from salvia miltiorrhiza anticoagulation group (45 patients) and conventional treatment group (45 patients).At the same time 50 normal were choosed as control group (50 patients).On the 14th day after treatment,4 indexes of coagulation,D-dimer and of blood rheology in depside salt from salvia miltiorrhiza anticoagulation group and conventional treatment group were determine and compared with those of normal control group.Results The levels of Fbg (4.6 ± 0.7) g/L and D-dimer (1.58 ± 1.13) mg/L were significantly different between depside salt from salvia miltiorrhiza anticoagulation group and normal controls.After depside salt from salvia miltiorrhiza anticoagulation,The levels of FbgFbg (3.3 ± 1.2) g/L and D-dimer (0.48 ± 0.36)mg/L were decreased significantly (P ＜ 0.01).The 1 evels of Fbg (3.3 ± 1.2) g/L and D-dimer (0.48 ± 0.36)mg/L were decreased significantly in depside salt from salvia miltiorrhiza anticoagulation group compared with those in Conventional treatment group (P ＜ 0.01).But PT,APTT and TT level were not significantly different in three groups (P ＜0.05).After treatment,hemodynamic indexes:whole blood high shearing viscosity (4.76 ± 1.35)mPa.S,low shearing viscosity (8.69 ± 2.36) mPa.S plasma viscosity (2.32 ± 0.26) mPa.S and hematocrit (40.3 ± 2.38)％ in depside salt from salvia miltiorrhiza anticoagulation group indicated significant differences compared to those in Conventional treatment group[(5.50.3 ± 1.34) mPa.S,(12.30 ± 2.30) mPa.S,(2.32 ± 0.26) mPa.S,(47.89 ± 3.13)％)] (P ＜ 0.01).Conclusion Patients with in AECOPD have hypercoagulable state.depside salt from salvia miltiorrhiza could improved hypercoagulable state in acute exacerbation of chronic obstructive pulmonary disease and decrease blood viscosity.
