CAJ | 학술논문

目的：探讨急性白血病患者合并院内感染的临床特点、危险因素及病原菌种类和耐药情况，为院内感染防治提供依据。方法选取急性白血病患者1758例，采用回顾性分析的方法对患者院内感染的部位、病原体及相关危险因素进行分析。结果1758例急性白血病患者中发生院内感染的有658例，感染率为37．42％，感染827例次，例次感染率为47．04％，感染部位以呼吸道，口腔、血液为主，住院天数及中性粒细胞缺乏时间为发生院内感染的独立因素，感染病原菌以革兰氏阴性杆菌为主，基本均对亚安培南敏感。诱导缓解的患者真菌感染比例高于未化疗及巩固治疗患者。结论急性白血病患者院内感染率高，为有效预防院内感染的发生，在保证治疗原发病同时，应缩短住院与中性粒细胞缺乏时间，合理使用抗菌药物。
목적：탐토급성백혈병환자합병원내감염적림상특점、위험인소급병원균충류화내약정황，위원내감염방치제공의거。방법선취급성백혈병환자1758례，채용회고성분석적방법대환자원내감염적부위、병원체급상관위험인소진행분석。결과1758례급성백혈병환자중발생원내감염적유658례，감염솔위37．42％，감염827례차，례차감염솔위47．04％，감염부위이호흡도，구강、혈액위주，주원천수급중성립세포결핍시간위발생원내감염적독립인소，감염병원균이혁란씨음성간균위주，기본균대아안배남민감。유도완해적환자진균감염비례고우미화료급공고치료환자。결론급성백혈병환자원내감염솔고，위유효예방원내감염적발생，재보증치료원발병동시，응축단주원여중성립세포결핍시간，합리사용항균약물。
Objective To investigate the clinical features of nosocomial infection and the characteristics of pathogens and treatment in patients with acute leukemia.Methods A total clinical data of 1 758 cases of acute leukemia patients were collected from acute leukemia in patients,and the risk factors,the site of infection,the pathogens of nosocomial infection in patients with acute leukemia were analyzed.Re-sults The prevalence of nosocomial infection was 37.42% among 1 758 patients,and the prevalence of time-cases was 47.04%.The main infection sites were respiratory tract,oral cavity and blood.The independent factor of nosocomial infection was hospital stays,agranulocytosis duration.The main pathogens were Escherichia coli,Klebsiella and S.aureus.The great majority of Gram-negative bacillus were sensitive to imipenem.The proportion of fungus in induction ease was higher than others.Conclusion Acute leukemia patients are the susceptible popu-lation of nosocomial infection,in our treatment,shortening the hospital stays and agranulocytosis time and rational use of antibiotics can effi-ciently reduce the prevalence of nosocomial infection.